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Neurotoxicity of Metals

Overview of attention for book
Attention for Chapter 2: Manganese and Developmental Neurotoxicity
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133 Mendeley
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Chapter title
Manganese and Developmental Neurotoxicity
Chapter number 2
Book title
Neurotoxicity of Metals
Published in
Advances in neurobiology, January 2017
DOI 10.1007/978-3-319-60189-2_2
Pubmed ID
Book ISBNs
978-3-31-960188-5, 978-3-31-960189-2

Roberto Lucchini, Donatella Placidi, Giuseppa Cagna, Chiara Fedrighi, Manuela Oppini, Marco Peli, Silvia Zoni


Manganese (Mn) is an essential metal that plays a fundamental role for brain development and functioning. Environmental exposure to Mn may lead to accumulation in the basal ganglia and development of Parkinson-like disorders. The most recent research is focusing on early-life overexposure to Mn and the potential vulnerability of younger individuals to Mn toxicity also in regard to cognitive and executive functions through the involvement of the frontal cortex.Neurodevelopmental disturbances are increasing in the society, and understanding the potential role of environmental determinants is a key for prevention. Therefore, assessing the environmental sources of Mn exposure and the mechanisms of developmental neurotoxicity and defining appropriate biomarkers of exposure and early functional alterations represent key issues to improve and address preventive strategies. These themes will be reviewed in this chapter.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 133 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 133 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 18 14%
Unspecified 14 11%
Researcher 14 11%
Student > Ph. D. Student 13 10%
Student > Bachelor 9 7%
Other 29 22%
Unknown 36 27%
Readers by discipline Count As %
Medicine and Dentistry 18 14%
Psychology 13 10%
Unspecified 13 10%
Environmental Science 8 6%
Neuroscience 6 5%
Other 34 26%
Unknown 41 31%