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Neurotoxicity of Metals

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Attention for Chapter 15: Neurotoxicity of Zinc.
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Chapter title
Neurotoxicity of Zinc.
Chapter number 15
Book title
Neurotoxicity of Metals
Published in
Advances in neurobiology, January 2017
DOI 10.1007/978-3-319-60189-2_15
Pubmed ID
Book ISBNs
978-3-31-960188-5, 978-3-31-960189-2

Morris, Deborah R, Levenson, Cathy W, Deborah R. Morris, Cathy W. Levenson


Zinc-induced neurotoxicity has been shown to play a role in neuronal damage and death associated with traumatic brain injury, stroke, seizures, and neurodegenerative diseases. During normal firing of "zinc-ergic" neurons, vesicular free zinc is released into the synaptic cleft where it modulates a number of postsynaptic neuronal receptors. However, excess zinc, released after injury or disease, leads to excitotoxic neuronal death. The mechanisms of zinc-mediated neurotoxicity appear to include not only neuronal signaling but also regulation of mitochondrial function and energy production, as well as other mechanisms such as aggregation of amyloid beta peptides in Alzheimer's disease. However, recent data have raised questions about some of our long-standing assumptions about the mechanisms of zinc in neurotoxicity. Thus, this review explores the most recent published findings and highlights the current mechanistic controversies.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 46 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 46 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 10 22%
Researcher 10 22%
Student > Bachelor 5 11%
Other 2 4%
Student > Master 1 2%
Other 3 7%
Unknown 15 33%
Readers by discipline Count As %
Medicine and Dentistry 9 20%
Neuroscience 7 15%
Biochemistry, Genetics and Molecular Biology 4 9%
Environmental Science 4 9%
Pharmacology, Toxicology and Pharmaceutical Science 3 7%
Other 5 11%
Unknown 14 30%