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Neurotoxicity of Metals

Overview of attention for book
Attention for Chapter 15: Neurotoxicity of Zinc.
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2 tweeters

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Chapter title
Neurotoxicity of Zinc.
Chapter number 15
Book title
Neurotoxicity of Metals
Published in
Advances in neurobiology, January 2017
DOI 10.1007/978-3-319-60189-2_15
Pubmed ID
Book ISBNs
978-3-31-960188-5, 978-3-31-960189-2
Authors

Morris, Deborah R, Levenson, Cathy W, Deborah R. Morris, Cathy W. Levenson

Abstract

Zinc-induced neurotoxicity has been shown to play a role in neuronal damage and death associated with traumatic brain injury, stroke, seizures, and neurodegenerative diseases. During normal firing of "zinc-ergic" neurons, vesicular free zinc is released into the synaptic cleft where it modulates a number of postsynaptic neuronal receptors. However, excess zinc, released after injury or disease, leads to excitotoxic neuronal death. The mechanisms of zinc-mediated neurotoxicity appear to include not only neuronal signaling but also regulation of mitochondrial function and energy production, as well as other mechanisms such as aggregation of amyloid beta peptides in Alzheimer's disease. However, recent data have raised questions about some of our long-standing assumptions about the mechanisms of zinc in neurotoxicity. Thus, this review explores the most recent published findings and highlights the current mechanistic controversies.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 37 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 37 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 8 22%
Student > Ph. D. Student 8 22%
Student > Bachelor 4 11%
Other 2 5%
Student > Master 1 3%
Other 1 3%
Unknown 13 35%
Readers by discipline Count As %
Medicine and Dentistry 9 24%
Neuroscience 6 16%
Pharmacology, Toxicology and Pharmaceutical Science 3 8%
Environmental Science 2 5%
Biochemistry, Genetics and Molecular Biology 1 3%
Other 4 11%
Unknown 12 32%