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Neurotoxicity of Metals

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Attention for Chapter 10: Copper and Alzheimer’s Disease
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Chapter title
Copper and Alzheimer’s Disease
Chapter number 10
Book title
Neurotoxicity of Metals
Published in
Advances in neurobiology, January 2017
DOI 10.1007/978-3-319-60189-2_10
Pubmed ID
Book ISBNs
978-3-31-960188-5, 978-3-31-960189-2
Authors

Zoe K. Mathys, Anthony R. White, Mathys, Zoe K., White, Anthony R.

Abstract

Alzheimer's disease (AD) is the most common form of adult neurode-generation and is characterised by progressive loss of cognitive function leading to death. The neuropathological hallmarks include extracellular amyloid plaque accumulation in affected regions of the brain, formation of intraneuronal neurofibrillary tangles, chronic neuroinflammation, oxidative stress, and abnormal biometal homeostasis. Of the latter, major changes in copper (Cu) levels and localisation have been identified in AD brain, with accumulation of Cu in amyloid deposits, together with deficiency of Cu in some brain regions. The amyloid precursor protein (APP) and the amyloid beta (Aβ) peptide both have Cu binding sites, and interaction with Cu can lead to potentially neurotoxic outcomes through generation of reactive oxygen species. In addition, AD patients have systemic changes to Cu metabolism, and altered Cu may also affect neuroinflammatory outcomes in AD. Although we still have much to learn about Cu homeostasis in AD patients and its role in disease aetiopathology, therapeutic approaches for regulating Cu levels and interactions with Cu-binding proteins in the brain are currently being developed. This review will examine how Cu is associated with pathological changes in the AD brain and how these may be targeted for therapeutic intervention.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 89 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 89 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 12 13%
Researcher 10 11%
Student > Ph. D. Student 10 11%
Student > Bachelor 8 9%
Professor > Associate Professor 8 9%
Other 17 19%
Unknown 24 27%
Readers by discipline Count As %
Chemistry 13 15%
Biochemistry, Genetics and Molecular Biology 12 13%
Agricultural and Biological Sciences 8 9%
Neuroscience 7 8%
Pharmacology, Toxicology and Pharmaceutical Science 5 6%
Other 12 13%
Unknown 32 36%