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Neurotoxicity of Metals

Overview of attention for book
Attention for Chapter 8: Inflammatory Activation of Microglia and Astrocytes in Manganese Neurotoxicity
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116 Mendeley
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Chapter title
Inflammatory Activation of Microglia and Astrocytes in Manganese Neurotoxicity
Chapter number 8
Book title
Neurotoxicity of Metals
Published in
Advances in neurobiology, January 2017
DOI 10.1007/978-3-319-60189-2_8
Pubmed ID
Book ISBNs
978-3-31-960188-5, 978-3-31-960189-2

Ronald B. Tjalkens, Katriana A. Popichak, Kelly A. Kirkley


Neurotoxicity due to excessive exposure to manganese (Mn) has been described as early as 1837 (Couper, Br Ann Med Pharm Vital Stat Gen Sci 1:41-42, 1837). Extensive research over the past two decades has revealed that Mn-induced neurological injury involves complex pathophysiological signaling mechanisms between neurons and glial cells. Glial cells are an important target of Mn in the brain, both for sequestration of the metal, as well as for activating inflammatory signaling pathways that damage neurons through overproduction of numerous reactive oxygen and nitrogen species and inflammatory cytokines. Understanding how these pathways are regulated in glial cells during Mn exposure is critical to determining the mechanisms underlying permanent neurological dysfunction stemming from excess exposure. The subject of this review will be to delineate mechanisms by which Mn interacts with glial cells to perturb neuronal function, with a particular emphasis on neuroinflammation and neuroinflammatory signaling between distinct populations of glial cells.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 116 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 116 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 20 17%
Student > Master 15 13%
Student > Bachelor 14 12%
Researcher 12 10%
Student > Doctoral Student 4 3%
Other 16 14%
Unknown 35 30%
Readers by discipline Count As %
Neuroscience 20 17%
Agricultural and Biological Sciences 17 15%
Biochemistry, Genetics and Molecular Biology 12 10%
Medicine and Dentistry 9 8%
Pharmacology, Toxicology and Pharmaceutical Science 5 4%
Other 12 10%
Unknown 41 35%