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Neurotoxicity of Metals

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Attention for Chapter 5: Metals and Paraoxonases.
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Chapter title
Metals and Paraoxonases.
Chapter number 5
Book title
Neurotoxicity of Metals
Published in
Advances in neurobiology, January 2017
DOI 10.1007/978-3-319-60189-2_5
Pubmed ID
Book ISBNs
978-3-31-960188-5, 978-3-31-960189-2

Costa, Lucio G, Cole, Toby B, Garrick, Jacqueline M, Marsillach, Judit, Furlong, Clement E, Lucio G. Costa, Toby B. Cole, Jacqueline M. Garrick, Judit Marsillach, Clement E. Furlong


The paraoxonases (PONs) are a three-gene family which includes PON1, PON2, and PON3. PON1 and PON3 are synthesized primarily in the liver and a portion is secreted in the plasma, where they are associated with high-density lipoproteins (HDLs), while PON2 is an intracellular enzyme, expressed in most tissues and organs, including the brain. PON1 received its name from its ability to hydrolyze paraoxon, the active metabolite of the organophosphorus (OP) insecticide parathion, and also more efficiently hydrolyzes the active metabolites of several other OPs. PON2 and PON3 do not have OP-esterase activity, but all PONs are lactonases and are capable of hydrolyzing a variety of lactones, including certain drugs, endogenous compounds, and quorum-sensing signals of pathogenic bacteria. In addition, all PONs exert potent antioxidant effects. PONs play important roles in cardiovascular diseases and other oxidative stress-related diseases, modulate susceptibility to infection, and may provide neuroprotection (PON2). Hence, significant attention has been devoted to their modulation by a variety of dietary, pharmacological, lifestyle, or environmental factors. A number of metals have been shown in in vitro, animal, and human studies to mostly negatively modulate expression of PONs, particularly PON1, the most studied in this regard. In addition, different levels of expression of PONs may affect susceptibility to toxicity and neurotoxicity of metals due to their aforementioned antioxidant properties.

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The data shown below were compiled from readership statistics for 28 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 28 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 4 14%
Student > Master 3 11%
Professor 2 7%
Student > Postgraduate 2 7%
Professor > Associate Professor 2 7%
Other 5 18%
Unknown 10 36%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 4 14%
Medicine and Dentistry 3 11%
Pharmacology, Toxicology and Pharmaceutical Science 2 7%
Unspecified 1 4%
Environmental Science 1 4%
Other 4 14%
Unknown 13 46%