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Neurotoxicity of Metals

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Attention for Chapter 1: Developmental Neurotoxicity of Lead
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Chapter title
Developmental Neurotoxicity of Lead
Chapter number 1
Book title
Neurotoxicity of Metals
Published in
Advances in neurobiology, September 2017
DOI 10.1007/978-3-319-60189-2_1
Pubmed ID
Book ISBNs
978-3-31-960188-5, 978-3-31-960189-2
Authors

Caito, Samuel, Aschner, Michael, Samuel Caito, Michael Aschner

Abstract

Lead exposure is a major concern for the developing nervous system. Environmental exposures to lead, predominantly from contaminated water or lead paint chips, account for the majority of exposures to children. In utero and early life exposures to lead have been associated with lower IQ, antisocial and delinquent behaviors, and attention-deficit hyperactivity disorder. In this review, we will discuss sources of developmental lead exposure and mechanisms of lead neurotoxicity. We will highlight both human epidemiological studies showing associations between lead exposure and behavioral abnormalities as well as experimental data from animal studies. Finally, we will discuss the effects of lead on neurological endpoint past childhood, namely, development of Alzheimer's disease in old age.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 84 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 84 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 12 14%
Student > Bachelor 12 14%
Student > Ph. D. Student 9 11%
Student > Master 8 10%
Professor 6 7%
Other 16 19%
Unknown 21 25%
Readers by discipline Count As %
Medicine and Dentistry 12 14%
Biochemistry, Genetics and Molecular Biology 7 8%
Agricultural and Biological Sciences 6 7%
Psychology 6 7%
Pharmacology, Toxicology and Pharmaceutical Science 5 6%
Other 19 23%
Unknown 29 35%