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Neurotoxicity of Metals

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Attention for Chapter 4: Chemical Speciation of Selenium and Mercury as Determinant of Their Neurotoxicity
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Chapter title
Chemical Speciation of Selenium and Mercury as Determinant of Their Neurotoxicity
Chapter number 4
Book title
Neurotoxicity of Metals
Published in
Advances in neurobiology, January 2017
DOI 10.1007/978-3-319-60189-2_4
Pubmed ID
Book ISBNs
978-3-31-960188-5, 978-3-31-960189-2

C. S. Oliveira, B. C. Piccoli, M. Aschner, J. B. T. Rocha, Oliveira, C. S., Piccoli, B. C., Aschner, M., Rocha, J. B. T.


The antagonism of mercury toxicity by selenium has been well documented. Mercury is a toxic metal, widespread in the environment. The main target organs (kidneys, lungs, or brain) of mercury vary depending on its chemical forms (inorganic or organic). Selenium is a semimetal essential to mammalian life as part of the amino acid selenocysteine, which is required to the synthesis of the selenoproteins. This chapter has the aim of disclosing the role of selenide or hydrogen selenide (Se(-2) or HSe(-)) as central metabolite of selenium and as an important antidote of the electrophilic mercury forms (particularly, Hg(2+) and MeHg). Emphasis will be centered on the neurotoxicity of electrophile forms of mercury and selenium. The controversial participation of electrophile mercury and selenium forms in the development of some neurodegenerative disease will be briefly presented. The potential pharmacological use of organoseleno compounds (Ebselen and diphenyl diselenide) in the treatment of mercury poisoning will be considered. The central role of thiol (-SH) and selenol (-SeH) groups as the generic targets of electrophile mercury forms and the need of new in silico tools to guide the future biological researches will be commented.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 58 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 58 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 11 19%
Researcher 10 17%
Student > Bachelor 9 16%
Student > Master 8 14%
Student > Doctoral Student 3 5%
Other 6 10%
Unknown 11 19%
Readers by discipline Count As %
Medicine and Dentistry 9 16%
Pharmacology, Toxicology and Pharmaceutical Science 7 12%
Biochemistry, Genetics and Molecular Biology 6 10%
Nursing and Health Professions 5 9%
Agricultural and Biological Sciences 5 9%
Other 12 21%
Unknown 14 24%