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Neurotoxicity of Metals

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Attention for Chapter 14: Neurotoxicity of Vanadium.
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Chapter title
Neurotoxicity of Vanadium.
Chapter number 14
Book title
Neurotoxicity of Metals
Published in
Advances in neurobiology, January 2017
DOI 10.1007/978-3-319-60189-2_14
Pubmed ID
Book ISBNs
978-3-31-960188-5, 978-3-31-960189-2

Ngwa, Hilary Afeseh, Ay, Muhammet, Jin, Huajun, Anantharam, Vellareddy, Kanthasamy, Arthi, Kanthasamy, Anumantha G, Hilary Afeseh Ngwa, Muhammet Ay, Huajun Jin, Vellareddy Anantharam, Arthi Kanthasamy, Anumantha G. Kanthasamy


Vanadium (V) is a transition metal that presents in multiple oxidation states and numerous inorganic compounds and is also an ultra-trace element considered to be essential for most living organisms. Despite being one of the lightest metals, V offers high structural strength and good corrosion resistance and thus has been widely adopted for high-strength steel manufacturing. High doses of V exposure are toxic, and inhalation exposure to V adversely affects the respiratory system. The neurotoxicological properties of V are just beginning to be identified. Recent studies by our group and others demonstrate the neurotoxic potential of this metal in the nigrostriatal system and other parts of the central nervous system (CNS). The neurotoxic effects of V have been mainly attributed to its ability to induce the generation of reactive oxygen species (ROS). It is noteworthy that the neurotoxicity induced by occupational V exposure commonly occurs with co-exposure to other metals, especially manganese (Mn). This review focuses on the chemistry, pharmacology, toxicology, and neurotoxicity of V.

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Geographical breakdown

Country Count As %
Unknown 20 100%

Demographic breakdown

Readers by professional status Count As %
Student > Doctoral Student 4 20%
Student > Ph. D. Student 4 20%
Student > Bachelor 2 10%
Other 1 5%
Unspecified 1 5%
Other 3 15%
Unknown 5 25%
Readers by discipline Count As %
Agricultural and Biological Sciences 2 10%
Nursing and Health Professions 2 10%
Pharmacology, Toxicology and Pharmaceutical Science 2 10%
Veterinary Science and Veterinary Medicine 1 5%
Biochemistry, Genetics and Molecular Biology 1 5%
Other 8 40%
Unknown 4 20%