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Neurotoxicity of Metals

Overview of attention for book
Attention for Chapter 3: Inherited Disorders of Manganese Metabolism
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Chapter title
Inherited Disorders of Manganese Metabolism
Chapter number 3
Book title
Neurotoxicity of Metals
Published in
Advances in neurobiology, January 2017
DOI 10.1007/978-3-319-60189-2_3
Pubmed ID
Book ISBNs
978-3-31-960188-5, 978-3-31-960189-2

Charles E. Zogzas, Somshuvra Mukhopadhyay


While the neurotoxic effects of manganese were recognized in 1837, the first genetic disorder of manganese metabolism was described only in 2012 when homozygous mutations in SLC30A10 were reported to cause manganese-induced neurotoxicity. Two other genetic disorders of manganese metabolism have now been described - mutations in SLC39A14 cause manganese toxicity, while mutations in SLC39A8 cause manganese and zinc deficiency. Study of rare genetic disorders often provides unique insights into disease pathobiology, and the discoveries of these three inherited disorders of manganese metabolism are already transforming our understanding of manganese homeostasis, detoxification, and neurotoxicity. Here, we review the mechanisms by which mutations in SLC30A10, SLC39A14, and SLC39A8 impact manganese homeostasis to cause human disease.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 14 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 14 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 3 21%
Student > Bachelor 1 7%
Student > Ph. D. Student 1 7%
Professor 1 7%
Researcher 1 7%
Other 1 7%
Unknown 6 43%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 3 21%
Medicine and Dentistry 3 21%
Agricultural and Biological Sciences 1 7%
Psychology 1 7%
Neuroscience 1 7%
Other 0 0%
Unknown 5 36%