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Neurotoxicity of Metals

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Attention for Chapter 9: Aluminum and Alzheimer's Disease.
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Chapter title
Aluminum and Alzheimer's Disease.
Chapter number 9
Book title
Neurotoxicity of Metals
Published in
Advances in neurobiology, January 2017
DOI 10.1007/978-3-319-60189-2_9
Pubmed ID
Book ISBNs
978-3-31-960188-5, 978-3-31-960189-2
Authors

Colomina, Maria Teresa, Peris-Sampedro, Fiona, Maria Teresa Colomina, Fiona Peris-Sampedro

Abstract

Aluminum (Al) is one of the most extended metals in the Earth's crust. Its abundance, together with the widespread use by humans, makes Al-related toxicity particularly relevant for human health.Despite some factors influence individual bioavailability to this metal after oral, dermal, or inhalation exposures, humans are considered to be protected against Al toxicity because of its low absorption and efficient renal excretion. However, several factors can modify Al absorption and distribution through the body, which may in turn progressively contribute to the development of silent chronic exposures that may lately trigger undesirable consequences to health. For instance, Al has been recurrently shown to cause encephalopathy, anemia, and bone disease in dialyzed patients. On the other hand, it remains controversial whether low doses of this metal may contribute to developing Alzheimer's disease (AD), probably because of the multifactorial and highly variable presentation of the disease.This chapter primarily focuses on two key aspects related to Al neurotoxicity and AD, which are metabolic impairment and iron (Fe) alterations. We discuss sex and genetic differences as a plausible source of bias to assess risk assessment in human populations.

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Mendeley readers

The data shown below were compiled from readership statistics for 169 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Malaysia 1 <1%
Spain 1 <1%
Netherlands 1 <1%
Iceland 1 <1%
Unknown 165 98%

Demographic breakdown

Readers by professional status Count As %
Researcher 20 12%
Student > Ph. D. Student 18 11%
Student > Master 17 10%
Student > Bachelor 12 7%
Other 11 7%
Other 30 18%
Unknown 61 36%
Readers by discipline Count As %
Medicine and Dentistry 21 12%
Agricultural and Biological Sciences 14 8%
Biochemistry, Genetics and Molecular Biology 10 6%
Pharmacology, Toxicology and Pharmaceutical Science 10 6%
Neuroscience 8 5%
Other 39 23%
Unknown 67 40%