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Neurotoxicity of Metals

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Attention for Chapter 18: Neurodegeneration Induced by Metals in Caenorhabditis elegans.
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Chapter title
Neurodegeneration Induced by Metals in Caenorhabditis elegans.
Chapter number 18
Book title
Neurotoxicity of Metals
Published in
Advances in neurobiology, January 2017
DOI 10.1007/978-3-319-60189-2_18
Pubmed ID
Book ISBNs
978-3-31-960188-5, 978-3-31-960189-2
Authors

Soares, Felix Antunes, Fagundez, Daiandra Almeida, Avila, Daiana Silva, Felix Antunes Soares, Daiandra Almeida Fagundez, Daiana Silva Avila

Abstract

Metals are a component of a variety of ecosystems and organisms. They can generally be divided into essential and nonessential metals. The essential metals are involved in physiological processes once the deficiency of these metals has been associated with diseases. Although iron, manganese, copper, and zinc are important for life, it has been evidenced that they are also involved in neuronal damage in many neurodegenerative disorders. Nonessential metals, which are metals without physiological functions, are present in trace or higher levels in living organisms. Occupational, environmental, or deliberate exposures to lead, mercury, aluminum, and cadmium are clearly correlated with the increase of toxicity and varied kinds of pathological situations. Actually, the field of neurotoxicology needs to satisfy two opposing demands: the testing of a growing list of chemicals and resource limitations and ethical concerns associated with testing using traditional mammalian species. Toxicological assays using alternative animal models may relieve some of this pressure by allowing testing of more compounds while reducing expenses and using fewer mammals. The nervous system is by far the more complex system in C. elegans. Almost a third of their cells are neurons (302 neurons versus 959 cells in adult hermaphrodite). It initially underwent extensive development as a model organism in order to study the nervous system, and its neuronal lineage and the complete wiring diagram of its nervous system are stereotyped and fully described. The neurotransmission systems are phylogenetically conserved from nematodes to vertebrates, which allows for findings from C. elegans to be extrapolated and further confirmed in vertebrate systems. Different strains of C. elegans offer a new perspective on neurodegenerative processes. Some genes have been found to be related to neurodegeneration induced by metals. Studying these interactions may be an effective tool to slow neuronal loss and deterioration.

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Mendeley readers

The data shown below were compiled from readership statistics for 45 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 45 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 9 20%
Researcher 5 11%
Student > Master 4 9%
Student > Ph. D. Student 3 7%
Other 2 4%
Other 5 11%
Unknown 17 38%
Readers by discipline Count As %
Pharmacology, Toxicology and Pharmaceutical Science 6 13%
Biochemistry, Genetics and Molecular Biology 6 13%
Agricultural and Biological Sciences 4 9%
Medicine and Dentistry 3 7%
Nursing and Health Professions 2 4%
Other 5 11%
Unknown 19 42%