Chapter title |
Role of Chemokines in Shaping Macrophage Activity in AMD.
|
---|---|
Chapter number | 2 |
Book title |
Retinal Degenerative Diseases
|
Published in |
Advances in experimental medicine and biology, October 2015
|
DOI | 10.1007/978-3-319-17121-0_2 |
Pubmed ID | |
Book ISBNs |
978-3-31-917120-3, 978-3-31-917121-0
|
Authors |
Rutar, Matt, Provis, Jan M, Matt Rutar, Jan M Provis |
Abstract |
Age-related macular degeneration (AMD) is a multifactorial disorder that affects millions of individuals worldwide. While the advent of anti-VEGF therapy has allowed for effective treatment of neovascular 'wet' AMD, no treatments are available to mitigate the more prevalent 'dry' forms of the disease. A role for inflammatory processes in the progression of AMD has emerged over a period of many years, particularly the characterisation of leukocyte infiltrates in AMD-affected eyes, as well as in animal models. This review focuses on the burgeoning understanding of chemokines in the retina, and their potential role in shaping the recruitment and activation of macrophages in AMD. Understanding the mechanisms which promote macrophage activity in the degenerating retina may be key to controlling the potentially devastating consequences of inflammation in diseases such as AMD. |
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Unknown | 1 | 100% |
Demographic breakdown
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
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Unknown | 21 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 5 | 24% |
Student > Bachelor | 3 | 14% |
Researcher | 3 | 14% |
Other | 2 | 10% |
Student > Doctoral Student | 2 | 10% |
Other | 3 | 14% |
Unknown | 3 | 14% |
Readers by discipline | Count | As % |
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Nursing and Health Professions | 2 | 10% |
Agricultural and Biological Sciences | 2 | 10% |
Neuroscience | 2 | 10% |
Other | 4 | 19% |
Unknown | 4 | 19% |