Chapter title |
Quantitative Fundus Autofluorescence in Best Vitelliform Macular Dystrophy: RPE Lipofuscin is not Increased in Non-Lesion Areas of Retina
|
---|---|
Chapter number | 38 |
Book title |
Retinal Degenerative Diseases
|
Published in |
Advances in experimental medicine and biology, January 2016
|
DOI | 10.1007/978-3-319-17121-0_38 |
Pubmed ID | |
Book ISBNs |
978-3-31-917120-3, 978-3-31-917121-0
|
Authors |
Janet R. Sparrow, Tobias Duncker, Russell Woods, François C. Delori, Sparrow, Janet R., Duncker, Tobias, Woods, Russell, Delori, François C. |
Abstract |
Since the lipofuscin of retinal pigment epithelial (RPE) cells has been implicated in the pathogenesis of Best vitelliform macular dystrophy, we quantified fundus autofluorescence (quantitative fundus autofluorescence, qAF) as an indirect measure of RPE lipofuscin levels. Mean non-lesion qAF was found to be within normal limits for age. By spectral domain optical coherence tomography (SD-OCT) vitelliform lesions presented as fluid-filled subretinal detachments containing reflective material. We discuss photoreceptor outer segment debris as the source of the intense fluorescence of these lesions and loss of anion channel functioning as an explanation for the bullous photoreceptor-RPE detachment. Unexplained is the propensity of the disease for central retina. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 10 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 3 | 30% |
Student > Doctoral Student | 1 | 10% |
Student > Bachelor | 1 | 10% |
Other | 1 | 10% |
Student > Master | 1 | 10% |
Other | 3 | 30% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 5 | 50% |
Biochemistry, Genetics and Molecular Biology | 1 | 10% |
Agricultural and Biological Sciences | 1 | 10% |
Nursing and Health Professions | 1 | 10% |
Unknown | 2 | 20% |