Chapter title |
Embryonic Stem Cell-Derived Microvesicles: Could They be Used for Retinal Regeneration?
|
---|---|
Chapter number | 75 |
Book title |
Retinal Degenerative Diseases
|
Published in |
Advances in experimental medicine and biology, January 2016
|
DOI | 10.1007/978-3-319-17121-0_75 |
Pubmed ID | |
Book ISBNs |
978-3-31-917120-3, 978-3-31-917121-0
|
Authors |
Farber, Debora B, Katsman, Diana, Debora B. Farber, Diana Katsman, Farber, Debora B. |
Abstract |
Mouse embryonic stem cells (mESCs) release into the medium in which they are cultured heterogeneous populations of microvesicles (mESMVs), important components of cell-cell communication, that transfer their contents not only to other stem cells but also to cells of other origins. The purpose of these studies was to demonstrate that ESMVs could be the signals that lead the retinal progenitor Müller cells to de-differentiate and re-entry the cell cycle, followed by differentiation along retinal lineages. Indeed, we found that ESMVs induce these processes and change Müller cells' microenvironment towards a more permissive state for tissue regeneration. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 5% |
Unknown | 19 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 3 | 15% |
Student > Master | 3 | 15% |
Student > Ph. D. Student | 3 | 15% |
Other | 2 | 10% |
Researcher | 2 | 10% |
Other | 3 | 15% |
Unknown | 4 | 20% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 3 | 15% |
Agricultural and Biological Sciences | 3 | 15% |
Biochemistry, Genetics and Molecular Biology | 2 | 10% |
Arts and Humanities | 1 | 5% |
Veterinary Science and Veterinary Medicine | 1 | 5% |
Other | 3 | 15% |
Unknown | 7 | 35% |