Chapter title |
Aging Changes in Retinal Microglia and their Relevance to Age-related Retinal Disease
|
---|---|
Chapter number | 11 |
Book title |
Retinal Degenerative Diseases
|
Published in |
Advances in experimental medicine and biology, January 2016
|
DOI | 10.1007/978-3-319-17121-0_11 |
Pubmed ID | |
Book ISBNs |
978-3-31-917120-3, 978-3-31-917121-0
|
Authors |
Wenxin Ma, Wai T. Wong, Ma, Wenxin, Wong, Wai T. |
Abstract |
Age-related retinal diseases, such as age-related macular degeneration (AMD) and glaucoma, contain features of chronic retinal inflammation that may promote disease progression. However, the relationship between aging and neuroinflammation is unclear. Microglia are long-lived, resident immune cells of the retina, and mediate local neuroinflammatory reactions. We hypothesize that aging changes in microglia may be causally linked to neuroinflammatory changes underlying age-dependent retinal diseases. Here, we review the evidence for (1) how the retinal microglial phenotype changes with aging, (2) the factors that drive microglial aging in the retina, and (3) aging-related changes in microglial gene expression. We examine how these aspects of microglial aging changes may relate to pathogenic mechanisms of immune dysregulation driving the progression of age-related retinal disease. These relationships can highlight microglial aging as a novel target for the prevention and treatment of retinal disease. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 47 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 10 | 21% |
Student > Ph. D. Student | 7 | 15% |
Student > Bachelor | 5 | 11% |
Researcher | 5 | 11% |
Other | 5 | 11% |
Other | 5 | 11% |
Unknown | 10 | 21% |
Readers by discipline | Count | As % |
---|---|---|
Neuroscience | 11 | 23% |
Biochemistry, Genetics and Molecular Biology | 7 | 15% |
Medicine and Dentistry | 5 | 11% |
Agricultural and Biological Sciences | 3 | 6% |
Immunology and Microbiology | 3 | 6% |
Other | 7 | 15% |
Unknown | 11 | 23% |