Chapter title |
A Non-Canonical Role for β-Secretase in the Retina
|
---|---|
Chapter number | 44 |
Book title |
Retinal Degenerative Diseases
|
Published in |
Advances in experimental medicine and biology, October 2015
|
DOI | 10.1007/978-3-319-17121-0_44 |
Pubmed ID | |
Book ISBNs |
978-3-31-917120-3, 978-3-31-917121-0
|
Authors |
Qian, Qingwen, Mitter, Sayak K., Pay, S. Louise, Qi, Xiaoping, Rickman, Catherine Bowes, Grant, Maria B., Boulton, Michael E, Qingwen Qian, Sayak K. Mitter, S. Louise Pay, Xiaoping Qi, Catherine Bowes Rickman, Maria B. Grant, Michael E Boulton |
Abstract |
It has long been established that β-Secretase (BACE) plays a critical role in the formation of amyloid plaques in Alzheimer's Disease patients, but it is only recently that the importance of β-secretases in retinal pathophysiology has been recognized. BACE expression is elevated in response to stress, and downregulation results in lysosomal abnormalities and mitochondrial changes. Inhibition of BACE can lead to reduced retinal function, retinal thinning, lipofuscin accumulation and vascular dysfunction in mice. Furthermore, BACE inhibition accelerates choroidal neovascularization (CNV) in mice. We propose that BACE plays an important role in retinal homeostasis and that BACE upregulation in response to stress is a protective measure. |
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