Chapter title |
Retinal Degenerative Diseases
|
---|---|
Chapter number | 61 |
Book title |
Retinal Degenerative Diseases
|
Published in |
Advances in experimental medicine and biology, October 2015
|
DOI | 10.1007/978-3-319-17121-0_61 |
Pubmed ID | |
Book ISBNs |
978-3-31-917120-3, 978-3-31-917121-0
|
Authors |
Daly, Conor, Yin, Jun, Kennedy, Breandán N, Kennedy, Breandán N., Conor Daly, Jun Yin, Breandán N. Kennedy |
Abstract |
Previous studies report that retinitis pigmentosa (RP) patients treated with the histone deacetylase inhibitor (HDACi) valproic acid (VPA) present with improved visual fields and delayed vision loss. However, other studies report poor efficacy and safety of HDACi in other cohorts of retinal degeneration patients. Furthermore, the molecular mechanisms by which HDACi can improve visual function is unknown, albeit HDACi can attenuate pro-apoptotic stimuli and induce expression of neuroprotective factors. Thus, further analysis of HDACi is warranted in pre-clinical models of retinal degeneration including zebrafish. Analysis of HDAC expression in developing zebrafish reveals diverse temporal expression patterns during development and maturation of visual function. |
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Demographic breakdown
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Student > Bachelor | 3 | 18% |
Researcher | 2 | 12% |
Student > Postgraduate | 2 | 12% |
Student > Doctoral Student | 1 | 6% |
Other | 4 | 24% |
Unknown | 2 | 12% |
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Agricultural and Biological Sciences | 1 | 6% |
Other | 3 | 18% |
Unknown | 2 | 12% |