Chapter title |
Retinal Degenerative Diseases
|
---|---|
Chapter number | 40 |
Book title |
Retinal Degenerative Diseases
|
Published in |
Advances in experimental medicine and biology, January 2016
|
DOI | 10.1007/978-3-319-17121-0_40 |
Pubmed ID | |
Book ISBNs |
978-3-31-917120-3, 978-3-31-917121-0
|
Authors |
Furutani, Yuka, Ogino, Ken, Oishi, Akio, Gotoh, Norimoto, Makiyama, Yukiko, Oishi, Maho, Kurimoto, Masafumi, Yoshimura, Nagahisa, Yuka Furutani, Ken Ogino, Akio Oishi, Norimoto Gotoh, Yukiko Makiyama, Maho Oishi, Masafumi Kurimoto, Nagahisa Yoshimura |
Abstract |
To examine the similarity of wide-field fundus autofluorescence (FAF) imaging in inherited retinal dystrophy between siblings and between parents and their children. The subjects included 17 siblings (12 with retinitis pigmentosa and 5 with cone rod dystrophy) and 10 parent-child pairs (8 with retinitis pigmentosa and 2 with cone rod dystrophy). We quantified the similarity of wide-field FAF using image processing techniques of cropping, binarization, superimposition, and subtraction. The estimated similarity of the siblings was compared with that of the parent-child pairs and that of the age-matched unrelated patients. The similarity between siblings was significantly higher that of parent-child pairs or that of age-matched unrelated patients (P = 0.004 and P = 0.049, respectively). Wide-field FAF images were similar between siblings with inherited retinal dystrophy but different between parent-child pairs. This suggests that aging is a confounding factor in genotype-phenotype correlation studies. |
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