Chapter title |
Cell Cycle Proteins and Retinal Degeneration: Evidences of New Potential Therapeutic Targets.
|
---|---|
Chapter number | 49 |
Book title |
Retinal Degenerative Diseases
|
Published in |
Advances in experimental medicine and biology, January 2016
|
DOI | 10.1007/978-3-319-17121-0_49 |
Pubmed ID | |
Book ISBNs |
978-3-31-917120-3, 978-3-31-917121-0
|
Authors |
Arsenijevic, Yvan, Yvan Arsenijevic |
Abstract |
During different forms of neurodegenerative diseases, including the retinal degeneration, several cell cycle proteins are expressed in the dying neurons from Drosophila to human revealing that these proteins are a hallmark of neuronal degeneration. This is true for animal models of Alzheimer's, and Parkinson's diseases, Amyotrophic Lateral Sclerosis and for Retinitis Pigmentosa as well as for acute injuries such as stroke and light damage. Longitudinal investigation and loss-of-function studies attest that cell cycle proteins participate to the process of cell death although with different impacts, depending on the disease. In the retina, inhibition of cell cycle protein action can result to massive protection. Nonetheless, the dissection of the molecular mechanisms of neuronal cell death is necessary to develop adapted therapeutic tools to efficiently protect photoreceptors as well as other neuron types. |
X Demographics
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United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Spain | 2 | 5% |
United States | 1 | 3% |
Unknown | 34 | 92% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 11 | 30% |
Student > Ph. D. Student | 7 | 19% |
Researcher | 4 | 11% |
Student > Doctoral Student | 3 | 8% |
Other | 2 | 5% |
Other | 6 | 16% |
Unknown | 4 | 11% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 9 | 24% |
Biochemistry, Genetics and Molecular Biology | 5 | 14% |
Nursing and Health Professions | 3 | 8% |
Engineering | 3 | 8% |
Other | 4 | 11% |
Unknown | 4 | 11% |