Chapter title |
The Development of a Cat Model of Retinal Detachment and Re-attachment.
|
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Chapter number | 42 |
Book title |
Retinal Degenerative Diseases
|
Published in |
Advances in experimental medicine and biology, January 2016
|
DOI | 10.1007/978-3-319-17121-0_42 |
Pubmed ID | |
Book ISBNs |
978-3-31-917120-3, 978-3-31-917121-0
|
Authors |
Wassmer, Sarah, Leonard, Brian C, Coupland, Stuart G, Baker, Adam, Hamilton, John, Torlone, Renée, Zacks, David N, Tsilfidis, Catherine, Sarah Wassmer, Brian C. Leonard, Stuart G. Coupland, Adam Baker, John Hamilton, Renée Torlone, David N. Zacks, Catherine Tsilfidis, Leonard, Brian C., Coupland, Stuart G., Zacks, David N. |
Abstract |
We present an optimized surgical technique for feline retinal detachment which allows for natural re-attachment, reduces retinal scarring and vitreal bands, and allows central placement of the detachment in close proximity to the optic nerve. This enables imaging via Optical Coherence Tomography (OCT) and multifocal electroretinography (mfERG) analysis. Ideal detachment conditions involve a lensectomy followed by a three-port pars plana vitrectomy. A 16-20 % retinal detachment is induced by injecting 8 % C3F8 gas into the subretinal space in the central retina with a 42G cannula. The retinal detachment resolves approximately 6 weeks post-surgery. Imaging is enhanced by using a 7.5 and 20 diopter lens for OCT and mfERG fundus imaging, respectively, to compensate for the removed lens. |
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