Chapter title |
Personalized Medicine: Cell and Gene Therapy Based on Patient-Specific iPSC-Derived Retinal Pigment Epithelium Cells.
|
---|---|
Chapter number | 73 |
Book title |
Retinal Degenerative Diseases
|
Published in |
Advances in experimental medicine and biology, January 2016
|
DOI | 10.1007/978-3-319-17121-0_73 |
Pubmed ID | |
Book ISBNs |
978-3-31-917120-3, 978-3-31-917121-0
|
Authors |
Li, Yao, Chan, Lawrence, Nguyen, Huy V, Tsang, Stephen H, Yao Li, Lawrence Chan, Huy V Nguyen, Stephen H Tsang |
Abstract |
Interest in generating human induced pluripotent stem (iPS) cells for stem cell modeling of diseases has overtaken that of patient-specific human embryonic stem cells due to the ethical, technical, and political concerns associated with the latter. In ophthalmology, researchers are currently using iPS cells to explore various applications, including: (1) modeling of retinal diseases using patient-specific iPS cells; (2) autologous transplantation of differentiated retinal cells that undergo gene correction at the iPS cell stage via gene editing tools (e.g., CRISPR/Cas9, TALENs and ZFNs); and (3) autologous transplantation of patient-specific iPS-derived retinal cells treated with gene therapy. In this review, we will discuss the uses of patient-specific iPS cells for differentiating into retinal pigment epithelium (RPE) cells, uncovering disease pathophysiology, and developing new treatments such as gene therapy and cell replacement therapy via autologous transplantation. |
X Demographics
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United States | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
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Unknown | 57 | 100% |
Demographic breakdown
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Student > Bachelor | 14 | 25% |
Researcher | 11 | 19% |
Student > Ph. D. Student | 9 | 16% |
Student > Master | 5 | 9% |
Student > Doctoral Student | 2 | 4% |
Other | 9 | 16% |
Unknown | 7 | 12% |
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Biochemistry, Genetics and Molecular Biology | 16 | 28% |
Agricultural and Biological Sciences | 3 | 5% |
Unspecified | 2 | 4% |
Social Sciences | 2 | 4% |
Other | 7 | 12% |
Unknown | 7 | 12% |