Report for: CCN Proteins

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Chapter title	Design and Analysis of CCN Gene Activity Using CCN Knockout Mice Containing LacZ Reporters.
Chapter number	28
Book title	CCN Proteins
Published in	Methods in molecular biology, January 2017
DOI	10.1007/978-1-4939-6430-7_28
Pubmed ID	27734387
Book ISBNs	978-1-4939-6428-4, 978-1-4939-6430-7
Authors	Jie Jiang Ph.D., Zhengshan Hu, Karen M. Lyons Ph.D., Jie Jiang, Karen M. Lyons
Editors	Masaharu Takigawa
Abstract	Two developments have greatly facilitated the construction of CCN mutant mouse strains. The first is the availability of modified embryonic stem (ES) cells and mice developed through several large-scale government-sponsored research programs. The second is the advent of CRISPR/Cas9 technology. In this chapter, we describe the available mouse strains generated by gene targeting techniques and the CCN targeting vectors and genetically modified ES cells that are available for the generation of CCN mutant mice. Many of these mutant mouse lines and ES cells carry a β-galactosidase reporter that can be used to track CCN expression, facilitating phenotypic analysis and revealing new sites of CCN action. Therefore, we also describe a method for β-galactosidase staining.

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Unknown	1	100%

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Type	Count	As %
Members of the public	1	100%

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Readers by professional status	Count	As %
Student > Bachelor	1	50%
Student > Master	1	50%

Readers by discipline	Count	As %
Agricultural and Biological Sciences	1	50%
Medicine and Dentistry	1	50%

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This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 January 2018.

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#20,346,264

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#9,921

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#845

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CCN Proteins

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