Chapter title |
Reduction in Cerebral Oxygenation After Prolonged Exercise in Hypoxia is Related to Changes in Blood Pressure.
|
---|---|
Chapter number | 12 |
Book title |
Oxygen Transport to Tissue XXXVII
|
Published in |
Advances in experimental medicine and biology, January 2016
|
DOI | 10.1007/978-1-4939-3023-4_12 |
Pubmed ID | |
Book ISBNs |
978-1-4939-3022-7, 978-1-4939-3023-4
|
Authors |
Horiuchi, Masahiro, Dobashi, Shohei, Kiuchi, Masataka, Endo, Junko, Koyama, Katsuhiro, Subudhi, Andrew W, Masahiro Horiuchi, Shohei Dobashi, Masataka Kiuchi, Junko Endo, Katsuhiro Koyama, Andrew W. Subudhi |
Editors |
Clare E. Elwell, Terence S. Leung, David K. Harrison |
Abstract |
We investigated the relation between blood pressure and cerebral oxygenation (COX) immediately after exercise in ten healthy males. Subjects completed an exercise and recovery protocol while breathing either 21 % (normoxia) or 14.1 % (hypoxia) O2 in a randomized order. Each exercise session included four sets of cycling (30 min/set, 15 min rest) at 50 % of altitude-adjusted peak oxygen uptake, followed by 60 min of recovery. After exercise, mean arterial pressure (MAP; 87 ± 1 vs. 84 ± 1 mmHg, average values across the recovery period) and COX (68 ± 1 % vs. 58 ± 1 %) were lower in hypoxia compared to normoxia (P < 0.001). Changes in MAP and COX were correlated during the recovery period in hypoxia (r = 0.568, P < 0.001) but not during normoxia (r = 0.028, not significant). These results demonstrate that reductions in blood pressure following exercise in hypoxia are (1) more pronounced than in normoxia, and (2) associated with reductions in COX. Together, these results suggest an impairment in cerebral autoregulation as COX followed changes in MAP more passively in hypoxia than in normoxia. These findings could help explain the increased risk for postexercise syncope at high altitude. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Science communicators (journalists, bloggers, editors) | 1 | 50% |
Members of the public | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 30 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 3 | 10% |
Researcher | 3 | 10% |
Student > Master | 3 | 10% |
Student > Bachelor | 2 | 7% |
Student > Postgraduate | 2 | 7% |
Other | 6 | 20% |
Unknown | 11 | 37% |
Readers by discipline | Count | As % |
---|---|---|
Sports and Recreations | 3 | 10% |
Medicine and Dentistry | 2 | 7% |
Neuroscience | 2 | 7% |
Computer Science | 2 | 7% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 3% |
Other | 7 | 23% |
Unknown | 13 | 43% |