Chapter title |
Oxygen Transport to Tissue XXXVII
|
---|---|
Chapter number | 62 |
Book title |
Oxygen Transport to Tissue XXXVII
|
Published in |
Advances in experimental medicine and biology, January 2016
|
DOI | 10.1007/978-1-4939-3023-4_62 |
Pubmed ID | |
Book ISBNs |
978-1-4939-3022-7, 978-1-4939-3023-4
|
Authors |
Mitra, S, Subhabrata Mitra, Gemma Bale, Judith Meek, Sean Mathieson, Cristina Uria, Giles Kendall, Nicola J. Robertson, Ilias Tachtsidis |
Editors |
Clare E. Elwell, Terence S. Leung, David K. Harrison |
Abstract |
Neonatal stroke presents with features of encephalopathy and can result in significant morbidity and mortality. We investigated the cerebral metabolic and haemodynamic changes following neonatal stroke in a term infant at 24 h of life. Changes in oxidation state of cytochrome-c-oxidase (oxCCO) concentration were monitored along with changes in oxy- and deoxy- haemoglobin using a new broadband near-infrared spectroscopy (NIRS) system. Repeated transient changes in cerebral haemodynamics and metabolism were noted over a 3-h study period with decrease in oxyhaemoglobin (HbO2), deoxy haemoglobin (HHb) and oxCCO in both cerebral hemispheres without significant changes in systemic observations. A clear asymmetry was noted in the degree of change between the two cerebral hemispheres. Changes in cerebral oxygenation (measured as HbDiff = HbO2 - HHb) and cerebral metabolism (measured as oxCCO) were highly coupled on the injured side of the brain. |
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