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Oxygen Transport to Tissue XXXVII

Overview of attention for book
Cover of 'Oxygen Transport to Tissue XXXVII'

Table of Contents

  1. Altmetric Badge
    Book Overview
  2. Altmetric Badge
    Chapter 1 The Most Important Discovery of Science.
  3. Altmetric Badge
    Chapter 2 The Spatial Distribution of Absolute Skeletal Muscle Deoxygenation During Ramp-Incremental Exercise Is Not Influenced by Hypoxia.
  4. Altmetric Badge
    Chapter 3 Do Two Tissue Blood Volume Parameters Measured by Different Near-Infrared Spectroscopy Methods Show the Same Dynamics During Incremental Running?
  5. Altmetric Badge
    Chapter 4 Oxygen Transport to Tissue XXXVII
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    Chapter 5 Muscle Oxygenation During Running Assessed by Broad Band NIRS.
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    Chapter 6 Regional Differences in Muscle Energy Metabolism in Human Muscle by (31)P-Chemical Shift Imaging.
  8. Altmetric Badge
    Chapter 7 Sex-Related Difference in Muscle Deoxygenation Responses Between Aerobic Capacity-Matched Elderly Men and Women.
  9. Altmetric Badge
    Chapter 8 Effects of Low Volume Aerobic Training on Muscle Desaturation During Exercise in Elderly Subjects.
  10. Altmetric Badge
    Chapter 9 Differences in Contraction-Induced Hemodynamics and Surface EMG in Duchenne Muscular Dystrophy.
  11. Altmetric Badge
    Chapter 10 Changes in Cortical Oxyhaemoglobin Signal During Low-Intensity Cycle Ergometer Activity: A Near-Infrared Spectroscopy Study.
  12. Altmetric Badge
    Chapter 11 Validation of a New Semi-Automated Technique to Evaluate Muscle Capillarization.
  13. Altmetric Badge
    Chapter 12 Reduction in Cerebral Oxygenation After Prolonged Exercise in Hypoxia is Related to Changes in Blood Pressure.
  14. Altmetric Badge
    Chapter 13 The Pathway for Oxygen: Tutorial Modelling on Oxygen Transport from Air to Mitochondrion : The Pathway for Oxygen.
  15. Altmetric Badge
    Chapter 14 Simulation of Preterm Neonatal Brain Metabolism During Functional Neuronal Activation Using a Computational Model.
  16. Altmetric Badge
    Chapter 15 Hemoglobin Effects on Nitric Oxide Mediated Hypoxic Vasodilation.
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    Chapter 16 A Discussion on the Regulation of Blood Flow and Pressure.
  18. Altmetric Badge
    Chapter 17 Near Infrared Light Scattering Changes Following Acute Brain Injury.
  19. Altmetric Badge
    Chapter 18 Comparison of Cerebral Oxygen Saturation and Cerebral Perfusion Computed Tomography in Cerebral Blood Flow in Patients with Brain Injury
  20. Altmetric Badge
    Chapter 19 Detection of ROSC in Patients with Cardiac Arrest During Chest Compression Using NIRS: A Pilot Study.
  21. Altmetric Badge
    Chapter 20 Myocardial Microcirculation and Mitochondrial Energetics in the Isolated Rat Heart.
  22. Altmetric Badge
    Chapter 21 Tissue Discs: A 3D Model for Assessing Modulation of Tissue Oxygenation.
  23. Altmetric Badge
    Chapter 22 Hypoxia-Driven Adenosine Accumulation: A Crucial Microenvironmental Factor Promoting Tumor Progression
  24. Altmetric Badge
    Chapter 23 Approaching Oxygen-Guided Intensity-Modulated Radiation Therapy.
  25. Altmetric Badge
    Chapter 24 Hypoxia-Associated Marker CA IX Does Not Predict the Response of Locally Advanced Rectal Cancers to Neoadjuvant Chemoradiotherapy.
  26. Altmetric Badge
    Chapter 25 Impact of Oxygenation Status on (18)F-FDG Uptake in Solid Tumors.
  27. Altmetric Badge
    Chapter 26 Direct Evidence of the Link Between Energetic Metabolism and Proliferation Capacity of Cancer Cells In Vitro
  28. Altmetric Badge
    Chapter 27 Acidosis Promotes Metastasis Formation by Enhancing Tumor Cell Motility.
  29. Altmetric Badge
    Chapter 28 Preoperative Stress Conditioning in Humans: Is Oxygen the Drug of Choice?
  30. Altmetric Badge
    Chapter 29 In Vivo Imaging of Flavoprotein Fluorescence During Hypoxia Reveals the Importance of Direct Arterial Oxygen Supply to Cerebral Cortex Tissue.
  31. Altmetric Badge
    Chapter 30 Cardiovascular Adaptation in Response to Chronic Hypoxia in Awake Rats.
  32. Altmetric Badge
    Chapter 31 Prototyping the Experimental Setup to Quantify the Tissue Oxygen Consumption Rate and Its Preliminary Test.
  33. Altmetric Badge
    Chapter 32 Monitoring Intracellular Oxygen Concentration: Implications for Hypoxia Studies and Real-Time Oxygen Monitoring
  34. Altmetric Badge
    Chapter 33 Aging Effect on Post-recovery Hypofusion and Mortality Following Cardiac Arrest and Resuscitation in Rats.
  35. Altmetric Badge
    Chapter 34 Using fNIRS to Study Working Memory of Infants in Rural Africa.
  36. Altmetric Badge
    Chapter 35 Gender and Age Analyses of NIRS/STAI Pearson Correlation Coefficients at Resting State.
  37. Altmetric Badge
    Chapter 36 Effects of Cosmetic Therapy on Cognitive Function in Elderly Women Evaluated by Time-Resolved Spectroscopy Study
  38. Altmetric Badge
    Chapter 37 Effects of Acupuncture on Anxiety Levels and Prefrontal Cortex Activity Measured by Near-Infrared Spectroscopy: A Pilot Study.
  39. Altmetric Badge
    Chapter 38 Influence of Pleasant and Unpleasant Auditory Stimuli on Cerebral Blood Flow and Physiological Changes in Normal Subjects.
  40. Altmetric Badge
    Chapter 39 Spontaneous Fluctuations of PO2 in the Rabbit Somatosensory Cortex.
  41. Altmetric Badge
    Chapter 40 Effect of the Antioxidant Supplement Pyrroloquinoline Quinone Disodium Salt (BioPQQ™) on Cognitive Functions.
  42. Altmetric Badge
    Chapter 41 Estimation of Skin Blood Flow Artefacts in NIRS Signals During a Verbal Fluency Task.
  43. Altmetric Badge
    Chapter 42 Effect of Transcranial Direct Current Stimulation over the Primary Motor Cortex on Cerebral Blood Flow: A Time Course Study Using Near-infrared Spectroscopy.
  44. Altmetric Badge
    Chapter 43 Relationships Between Gum-Chewing and Stress.
  45. Altmetric Badge
    Chapter 44 Effects of Anodal High-Definition Transcranial Direct Current Stimulation on Bilateral Sensorimotor Cortex Activation During Sequential Finger Movements: An fNIRS Study.
  46. Altmetric Badge
    Chapter 45 Towards Human Oxygen Images with Electron Paramagnetic Resonance Imaging.
  47. Altmetric Badge
    Chapter 46 Evaluation of Brown Adipose Tissue Using Near-Infrared Time-Resolved Spectroscopy.
  48. Altmetric Badge
    Chapter 47 Near-Infrared Image Reconstruction of Newborns' Brains: Robustness to Perturbations of the Source/Detector Location.
  49. Altmetric Badge
    Chapter 48 Simultaneous Measurement of Dissolved Oxygen Pressure and Oxyhemoglobin Spectra in Solution.
  50. Altmetric Badge
    Chapter 49 Local Measurement of Flap Oxygen Saturation: An Application of Visible Light Spectroscopy.
  51. Altmetric Badge
    Chapter 50 Hemodynamic Measurements of the Human Adult Head in Transmittance Mode by Near-Infrared Time-Resolved Spectroscopy.
  52. Altmetric Badge
    Chapter 51 Non-invasive Monitoring of Hepatic Oxygenation Using Time-Resolved Spectroscopy.
  53. Altmetric Badge
    Chapter 52 Comparison of Near-Infrared Oximeters in a Liquid Optical Phantom with Varying Intralipid and Blood Content.
  54. Altmetric Badge
    Chapter 53 Improvement of Speckle Contrast Image Processing by an Efficient Algorithm.
  55. Altmetric Badge
    Chapter 54 A Clinical Tissue Oximeter Using NIR Time-Resolved Spectroscopy.
  56. Altmetric Badge
    Chapter 55 Validation of a Hybrid Microwave-Optical Monitor to Investigate Thermal Provocation in the Microvasculature.
  57. Altmetric Badge
    Chapter 56 Possibilities of Using Fetal Hemoglobin as a Platform for Producing Hemoglobin-Based Oxygen Carriers (HBOCs).
  58. Altmetric Badge
    Chapter 57 The βLys66Tyr Variant of Human Hemoglobin as a Component of a Blood Substitute.
  59. Altmetric Badge
    Chapter 58 PEGylated Bovine Carboxyhemoglobin (SANGUINATE™): Results of Clinical Safety Testing and Use in Patients.
  60. Altmetric Badge
    Chapter 59 Oxygen Supplementation is Effective in Attenuating Maternal Cerebral Blood Deoxygenation After Spinal Anesthesia for Cesarean Section.
  61. Altmetric Badge
    Chapter 60 Changes in Cerebral Blood Flow and Oxygenation During Induction of General Anesthesia with Sevoflurane Versus Propofol.
  62. Altmetric Badge
    Chapter 61 Neurovascular Interactions in the Neurologically Compromised Neonatal Brain.
  63. Altmetric Badge
    Chapter 62 Oxygen Transport to Tissue XXXVII
  64. Altmetric Badge
    Chapter 63 A New Framework for the Assessment of Cerebral Hemodynamics Regulation in Neonates Using NIRS.
  65. Altmetric Badge
    Chapter 64 Characterizing Fluctuations of Arterial and Cerebral Tissue Oxygenation in Preterm Neonates by Means of Data Analysis Techniques for Nonlinear Dynamical Systems.
  66. Altmetric Badge
    Chapter 65 Can the Assessment of Spontaneous Oscillations by Near Infrared Spectrophotometry Predict Neurological Outcome of Preterm Infants?
  67. Altmetric Badge
    Chapter 66 Oxygen Transport to Tissue XXXVII
Attention for Chapter 40: Effect of the Antioxidant Supplement Pyrroloquinoline Quinone Disodium Salt (BioPQQ™) on Cognitive Functions.
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (87th percentile)
  • High Attention Score compared to outputs of the same age and source (87th percentile)

Mentioned by

18 tweeters
2 Facebook pages
2 Redditors
1 video uploader


18 Dimensions

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76 Mendeley
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Chapter title
Effect of the Antioxidant Supplement Pyrroloquinoline Quinone Disodium Salt (BioPQQ™) on Cognitive Functions.
Chapter number 40
Book title
Oxygen Transport to Tissue XXXVII
Published in
Advances in experimental medicine and biology, January 2016
DOI 10.1007/978-1-4939-3023-4_40
Pubmed ID
Book ISBNs
978-1-4939-3022-7, 978-1-4939-3023-4

Itoh, Yuji, Hine, Kyoko, Miura, Hiroshi, Uetake, Tatsuo, Nakano, Masahiko, Takemura, Naohiro, Sakatani, Kaoru, Yuji Itoh, Kyoko Hine, Hiroshi Miura, Tatsuo Uetake, Masahiko Nakano, Naohiro Takemura, Kaoru Sakatani


Clare E. Elwell, Terence S. Leung, David K. Harrison


Pyrroloquinoline quinone (PQQ) is a quinone compound first identified in 1979. It has been reported that rats fed a PQQ-supplemented diet showed better learning ability than controls, suggesting that PQQ may be useful for improving memory in humans. In the present study, a randomized, placebo-controlled, double-blinded study to examine the effect of PQQ disodium salt (BioPQQ™) on cognitive functions was conducted with 41 elderly healthy subjects. Subjects were orally given 20 mg of BioPQQ™ per day or placebo, for 12 weeks. For cognitive functions, selective attention by the Stroop and reverse Stroop test, and visual-spatial cognitive function by the laptop tablet Touch M, were evaluated. In the Stroop test, the change of Stroop interference ratios (SIs) for the PQQ group was significantly smaller than for the placebo group. In the Touch M test, the stratification analyses dividing each group into two groups showed that only in the lower group of the PQQ group (initial score < 70), did the score significantly increase. Measurements of physiological parameters indicated no abnormal blood or urinary adverse events, nor adverse internal or physical examination findings at any point in the study. The preliminary experiment using near-infrared spectrometry (NIRS) suggests that cerebral blood flow in the prefrontal cortex was increased by the administration of PQQ. The results suggest that PQQ can prevent reduction of brain function in aged persons, especially in attention and working memory.

Twitter Demographics

The data shown below were collected from the profiles of 18 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 76 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 76 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 11 14%
Unspecified 10 13%
Student > Ph. D. Student 9 12%
Researcher 8 11%
Student > Bachelor 7 9%
Other 16 21%
Unknown 15 20%
Readers by discipline Count As %
Medicine and Dentistry 12 16%
Unspecified 10 13%
Agricultural and Biological Sciences 7 9%
Psychology 5 7%
Neuroscience 5 7%
Other 21 28%
Unknown 16 21%

Attention Score in Context

This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 January 2023.
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Outputs from Advances in experimental medicine and biology
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Outputs of similar age from Advances in experimental medicine and biology
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Altmetric has tracked 23,565,002 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,038 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.3. This one has done particularly well, scoring higher than 91% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 397,054 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 87% of its contemporaries.
We're also able to compare this research output to 447 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 87% of its contemporaries.