Chapter title |
Hypoxia-Associated Marker CA IX Does Not Predict the Response of Locally Advanced Rectal Cancers to Neoadjuvant Chemoradiotherapy.
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Chapter number | 24 |
Book title |
Oxygen Transport to Tissue XXXVII
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Published in |
Advances in experimental medicine and biology, January 2016
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DOI | 10.1007/978-1-4939-3023-4_24 |
Pubmed ID | |
Book ISBNs |
978-1-4939-3022-7, 978-1-4939-3023-4
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Authors |
Mayer, Arnulf, Vaupel, Peter, Oberholzer, Katja, Ebert, Maren, Dimitrow, Marc, Kreft, Andreas, Mueller-Klieser, Wolfgang, Schmidberger, Heinz, Arnulf Mayer, Peter Vaupel, Katja Oberholzer, Maren Ebert, Marc Dimitrow, Andreas Kreft, Wolfgang Mueller-Klieser, Heinz Schmidberger |
Editors |
Clare E. Elwell, Terence S. Leung, David K. Harrison |
Abstract |
Hypoxia-associated proteome changes have been shown to be associated with resistance to chemo- and radiotherapy. Our study evaluated the role of the hypoxia-inducible (HIF)-1 target gene carbonic anhydrase (CA) IX in the prediction of the response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer (stages II and III). A total of 29 pretreatment biopsy specimens were stained for CA IX by immunohistochemistry, converted to digital images and evaluated in a quantitative fashion using image analysis software. Contrary to our expectations, a trend towards a correlation between better tumor regression (>50 %) and higher expression of CA IX (p = 0.056) was found. CA IX was also present more frequently in pathological tumor stage T1 (pT1) tumors (p = 0.048). Conversely, no association with lymph node metastasis was identified. In conclusion, as a single marker, CA IX expression is not able to identify a hypoxia-related treatment resistant phenotype in rectal cancer. |
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Other | 2 | 14% |
Student > Master | 2 | 14% |
Professor | 2 | 14% |
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