Chapter title |
Evaluation of Brown Adipose Tissue Using Near-Infrared Time-Resolved Spectroscopy.
|
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Chapter number | 46 |
Book title |
Oxygen Transport to Tissue XXXVII
|
Published in |
Advances in experimental medicine and biology, January 2016
|
DOI | 10.1007/978-1-4939-3023-4_46 |
Pubmed ID | |
Book ISBNs |
978-1-4939-3022-7, 978-1-4939-3023-4
|
Authors |
Shinsuke Nirengi, Takeshi Yoneshiro, Takeshi Saiki, Sayuri Aita, Mami Matsushita, Hiroki Sugie, Masayuki Saito, Takafumi Hamaoka |
Editors |
Clare E. Elwell, Terence S. Leung, David K. Harrison |
Abstract |
Human brown adipose tissue (BAT) activity (SUVmax) has been typically evaluated by (18)F-fluorodeoxy glucose (FDG)-positron emission tomography (PET) combined with computed tomography (CT). In this study, the objective was to detect human BAT by near-infrared time-resolved spectroscopy (NIRTRS), a noninvasive and simple method for measuring total hemoglobin concentration [total-Hb] and reduced scattering coefficient (μs') in the tissue. The [total-Hb] in the supraclavicular region of the BAT (+) (SUVmax ≥ 2.0) group was 95.0 ± 28.2 μM (mean +/- SD), which was significantly higher than that of the BAT (-) (SUVmax < 2.0) group (52.0 ± 14.8 μM), but not in other regions apart from the BAT deposits. The μs' in the supraclavicular region of the BAT (+) group was 8.4 ± 1.7 cm(-1), which was significantly higher than that of BAT (-) group (4.3 ± 1.0 cm(-1)), but not in other regions. The area under the receiver operating characteristic curve closest to (0, 1) for [total-Hb] and μs' to discriminate BAT (+) from BAT (-) was 72.5 μM and 6.3 cm(-1), respectively. The sensitivity, specificity, and accuracy for both parameters were 87.5, 100, and 93.3 %, respectively. Our novel NIRTRS method is noninvasive, simple, and inexpensive compared with FDG-PET/CT, and is reliable for detecting human BAT. |
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