Sex and Gender Factors Affecting Metabolic Homeostasis, Diabetes and Obesity
Springer, Cham
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Mendeley readers
| Chapter title |
Prenatal Testosterone Programming of Insulin Resistance in the Female Sheep
|
|---|---|
| Chapter number | 25 |
| Book title |
Sex and Gender Factors Affecting Metabolic Homeostasis, Diabetes and Obesity
|
| Published in |
Advances in experimental medicine and biology, January 2017
|
| DOI | 10.1007/978-3-319-70178-3_25 |
| Pubmed ID | |
| Book ISBNs |
978-3-31-970177-6, 978-3-31-970178-3
|
| Authors |
Muraly Puttabyatappa, Vasantha Padmanabhan, Puttabyatappa, Muraly, Padmanabhan, Vasantha |
| Abstract |
Insulin resistance, a common feature of metabolic disorders such as obesity, nonalcoholic fatty liver disease, metabolic syndrome, and polycystic ovary syndrome, is a risk factor for development of diabetes. Because sex hormones orchestrate the establishment of sex-specific behavioral, reproductive, and metabolic differences, a role for them in the developmental origin of insulin resistance is also to be expected. Female sheep exposed to male levels of testosterone during fetal life serve as an excellent translational model for delineating programming of insulin resistance. This chapter summarizes the ontogeny of insulin resistance, the tissue-specific changes in insulin sensitivity, and the various factors that are involved in the programming and maintenance of the insulin resistance in adult female sheep that were developmentally exposed to fetal male levels of testosterone during the sexual-differentiation window. |
Mendeley readers
The data shown below were compiled from readership statistics for 34 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 34 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 8 | 24% |
| Researcher | 5 | 15% |
| Student > Ph. D. Student | 4 | 12% |
| Student > Doctoral Student | 3 | 9% |
| Student > Bachelor | 2 | 6% |
| Other | 3 | 9% |
| Unknown | 9 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 6 | 18% |
| Medicine and Dentistry | 4 | 12% |
| Biochemistry, Genetics and Molecular Biology | 4 | 12% |
| Nursing and Health Professions | 2 | 6% |
| Unspecified | 1 | 3% |
| Other | 5 | 15% |
| Unknown | 12 | 35% |