Chapter title |
The Role of Estrogens in Pancreatic Islet Physiopathology
|
---|---|
Chapter number | 18 |
Book title |
Sex and Gender Factors Affecting Metabolic Homeostasis, Diabetes and Obesity
|
Published in |
Advances in experimental medicine and biology, January 2017
|
DOI | 10.1007/978-3-319-70178-3_18 |
Pubmed ID | |
Book ISBNs |
978-3-31-970177-6, 978-3-31-970178-3
|
Authors |
Franck Mauvais-Jarvis, Cedric Le May, Joseph P. Tiano, Suhuan Liu, Gamze Kilic-Berkmen, Jun Ho Kim |
Abstract |
In rodent models of insulin-deficient diabetes, 17β-estradiol (E2) protects pancreatic insulin-producing β-cells against oxidative stress, amyloid polypeptide toxicity, gluco-lipotoxicity, and apoptosis. Three estrogen receptors (ERs)-ERα, ERβ, and the G protein-coupled ER (GPER)-have been identified in rodent and human β-cells. This chapter describes recent advances in our understanding of the role of ERs in islet β-cell function, nutrient homeostasis, survival from pro-apoptotic stimuli, and proliferation. We discuss why and how ERs represent potential therapeutic targets for the maintenance of functional β-cell mass. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 31 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 5 | 16% |
Student > Doctoral Student | 3 | 10% |
Student > Bachelor | 3 | 10% |
Student > Master | 3 | 10% |
Student > Ph. D. Student | 2 | 6% |
Other | 2 | 6% |
Unknown | 13 | 42% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 7 | 23% |
Medicine and Dentistry | 4 | 13% |
Agricultural and Biological Sciences | 1 | 3% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 3% |
Social Sciences | 1 | 3% |
Other | 1 | 3% |
Unknown | 16 | 52% |