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Zebrafish

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Cover of 'Zebrafish'

Table of Contents

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    Book Overview
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    Chapter 1 Chemical Screening in Zebrafish
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    Chapter 2 TALEN-Mediated Mutagenesis and Genome Editing
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    Chapter 3 Zebrafish
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    Chapter 4 Detection of Multiple Genome Modifications Induced by the CRISPR/Cas9 System
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    Chapter 5 Generation of Targeted Genomic Deletions Through CRISPR/Cas System in Zebrafish
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    Chapter 6 Testing of Cis -Regulatory Elements by Targeted Transgene Integration in Zebrafish Using PhiC31 Integrase
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    Chapter 7 Zebrafish
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    Chapter 8 Construction of the Inbred Strain
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    Chapter 9 Zebrafish as a Model for the Study of Solid Malignancies
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    Chapter 10 Melanoma Regression and Recurrence in Zebrafish
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    Chapter 11 Imaging of Human Cancer Cell Proliferation, Invasion, and Micrometastasis in a Zebrafish Xenogeneic Engraftment Model
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    Chapter 12 Modeling Leukemogenesis in the Zebrafish Using Genetic and Xenograft Models
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    Chapter 13 Zebrafish
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    Chapter 14 Zebrafish
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    Chapter 15 Zebrafish
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    Chapter 16 Studying Lipid Metabolism and Transport During Zebrafish Development
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    Chapter 17 Targeted Electroporation in Embryonic, Larval, and Adult Zebrafish
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    Chapter 18 Studying Axonal Regeneration by Laser Microsurgery and High-Resolution Videomicroscopy
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    Chapter 19 Zebrafish
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    Chapter 20 Quantifying Aggressive Behavior in Zebrafish
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    Chapter 21 Correlating Whole Brain Neural Activity with Behavior in Head-Fixed Larval Zebrafish
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    Chapter 22 A Practical Guide to Light Sheet Microscopy
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    Chapter 23 Calcium Imaging of Neuronal Activity in Free-Swimming Larval Zebrafish
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    Chapter 24 Fiber Optic-Based Photostimulation of Larval Zebrafish
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    Chapter 25 Genetic Ablation, Sensitization, and Isolation of Neurons Using Nitroreductase and Tetrodotoxin-Insensitive Channels
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    Chapter 26 Erratum
Attention for Chapter 9: Zebrafish as a Model for the Study of Solid Malignancies
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Chapter title
Zebrafish as a Model for the Study of Solid Malignancies
Chapter number 9
Book title
Zebrafish
Published in
Methods in molecular biology, January 2016
DOI 10.1007/978-1-4939-3771-4_9
Pubmed ID
Book ISBNs
978-1-4939-3769-1, 978-1-4939-3771-4
Authors

Genevieve C. Kendall, James F. Amatruda, Kendall, Genevieve C., Amatruda, James F.

Abstract

Zebrafish cancer models have provided critical insight into understanding the link between aberrant developmental pathways and tumorigenesis. The unique strengths of zebrafish as compared to other vertebrate model systems include the combination of fecundity, readily available and efficient transgenesis techniques, transparency that facilitates in vivo cell lineage tracing, and amenability for high-throughput applications. In addition to early embryo readouts, zebrafish can develop tumors at ages ranging from 2 weeks old to adulthood. Tumorigenesis is driven by genetically introducing oncogenes using selected promoter/tissue-specific expression, with either mosaic expression or with the generation of a stable transgenic line. Here, we detail a research pipeline to facilitate the study of human oncogenes in zebrafish systems. The goals of this approach are to identify conserved developmental pathways that may be critical for tumor development and to create platforms for testing novel therapies.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 12 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 12 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 3 25%
Student > Master 2 17%
Researcher 2 17%
Student > Ph. D. Student 1 8%
Unknown 4 33%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 3 25%
Agricultural and Biological Sciences 3 25%
Veterinary Science and Veterinary Medicine 1 8%
Medicine and Dentistry 1 8%
Unknown 4 33%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 March 2023.
All research outputs
#20,846,788
of 23,462,326 outputs
Outputs from Methods in molecular biology
#10,122
of 13,337 outputs
Outputs of similar age
#333,493
of 396,737 outputs
Outputs of similar age from Methods in molecular biology
#1,077
of 1,472 outputs
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So far Altmetric has tracked 13,337 research outputs from this source. They receive a mean Attention Score of 3.4. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 1,472 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.