Zebrafish
Humana Press
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Timeline
Mendeley readers
| Chapter title |
Melanoma Regression and Recurrence in Zebrafish
|
|---|---|
| Chapter number | 10 |
| Book title |
Zebrafish
|
| Published in |
Methods in molecular biology, January 2016
|
| DOI | 10.1007/978-1-4939-3771-4_10 |
| Pubmed ID | |
| Book ISBNs |
978-1-4939-3769-1, 978-1-4939-3771-4
|
| Authors |
Sonia Wojciechowska, Zhiqiang Zeng, James A. Lister, Craig J. Ceol, E. Elizabeth Patton, Wojciechowska, Sonia, Zeng, Zhiqiang, Lister, James A., Ceol, Craig J., Patton, E. Elizabeth |
| Abstract |
Melanoma is the most lethal form of skin cancer with high mortality rates. Most melanoma cases have activating mutations in BRAF (V600E) and the selective inhibitors of BRAF(V600E) have been successfully used in patients. However, after initial tumor regression, the majority of patients develop drug resistance resulting in tumor regrowth. It is therefore important to understand the mechanisms underlying these processes. We have recently described the role of the master melanocyte transcription factor MITF in tumor growth, regression, and recurrence. Here, we describe protocols to study regression and recurrence in vivo, as well as for histology and immunohistochemistry, using a temperature-sensitive zebrafish model of human melanoma. |
Mendeley readers
The data shown below were compiled from readership statistics for 10 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Portugal | 1 | 10% |
| Unknown | 9 | 90% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 2 | 20% |
| Student > Ph. D. Student | 2 | 20% |
| Unspecified | 1 | 10% |
| Other | 1 | 10% |
| Student > Bachelor | 1 | 10% |
| Other | 0 | 0% |
| Unknown | 3 | 30% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 5 | 50% |
| Unspecified | 1 | 10% |
| Medicine and Dentistry | 1 | 10% |
| Unknown | 3 | 30% |