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| Chapter title |
Chemical Screening in Zebrafish
|
|---|---|
| Chapter number | 1 |
| Book title |
Zebrafish
|
| Published in |
Methods in molecular biology, January 2016
|
| DOI | 10.1007/978-1-4939-3771-4_1 |
| Pubmed ID | |
| Book ISBNs |
978-1-4939-3769-1, 978-1-4939-3771-4
|
| Authors |
Colleen A. Brady, Andrew J. Rennekamp, Randall T. Peterson, Brady, Colleen A., Rennekamp, Andrew J., Peterson, Randall T. |
| Abstract |
Phenotypic small molecule screens in zebrafish have gained popularity as an unbiased approach to probe biological processes. In this chapter we outline basic methods for performing chemical screens with larval zebrafish including breeding large numbers of embryos, plating larval fish into multi-well dishes, and adding small molecules to these wells. We also highlight important considerations when designing and interpreting the results of a phenotypic screen and possible follow-up approaches, including popular methods used to identify the mechanism of action of a chemical compound. |
Mendeley readers
The data shown below were compiled from readership statistics for 17 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 17 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 6 | 35% |
| Student > Master | 3 | 18% |
| Student > Ph. D. Student | 2 | 12% |
| Other | 1 | 6% |
| Student > Bachelor | 1 | 6% |
| Other | 2 | 12% |
| Unknown | 2 | 12% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 5 | 29% |
| Agricultural and Biological Sciences | 4 | 24% |
| Neuroscience | 4 | 24% |
| Medicine and Dentistry | 1 | 6% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 6% |
| Other | 0 | 0% |
| Unknown | 2 | 12% |