Chapter title |
The Web-Based DNA Vaccine Database DNAVaxDB and Its Usage for Rational DNA Vaccine Design.
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Chapter number | 48 |
Book title |
Vaccine Design
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Published in |
Methods in molecular biology, January 2016
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DOI | 10.1007/978-1-4939-3389-1_48 |
Pubmed ID | |
Book ISBNs |
978-1-4939-3388-4, 978-1-4939-3389-1
|
Authors |
Rebecca Racz, Yongqun He |
Editors |
Sunil Thomas |
Abstract |
A DNA vaccine is a vaccine that uses a mammalian expression vector to express one or more protein antigens and is administered in vivo to induce an adaptive immune response. Since the 1990s, a significant amount of research has been performed on DNA vaccines and the mechanisms behind them. To meet the needs of the DNA vaccine research community, we created DNAVaxDB ( http://www.violinet.org/dnavaxdb ), the first Web-based database and analysis resource of experimentally verified DNA vaccines. All the data in DNAVaxDB, which includes plasmids, antigens, vaccines, and sources, is manually curated and experimentally verified. This chapter goes over the detail of DNAVaxDB system and shows how the DNA vaccine database, combined with the Vaxign vaccine design tool, can be used for rational design of a DNA vaccine against a pathogen, such as Mycobacterium bovis. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 6 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 2 | 33% |
Other | 1 | 17% |
Student > Postgraduate | 1 | 17% |
Unknown | 2 | 33% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 2 | 33% |
Medicine and Dentistry | 2 | 33% |
Unknown | 2 | 33% |