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Interrelations between Essential Metal Ions and Human Diseases

Overview of attention for book
Attention for Chapter 16: Selenium. Role of the Essential Metalloid in Health
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About this Attention Score

  • Among the highest-scoring outputs from this source (#38 of 118)
  • Above-average Attention Score compared to outputs of the same age (61st percentile)

Mentioned by

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67 Mendeley
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Chapter title
Selenium. Role of the Essential Metalloid in Health
Chapter number 16
Book title
Interrelations between Essential Metal Ions and Human Diseases
Published in
Metal ions in life sciences, November 2013
DOI 10.1007/978-94-007-7500-8_16
Pubmed ID
Book ISBNs
978-9-40-077499-5, 978-9-40-077500-8

Suguru Kurokawa, Marla J. Berry


Astrid Sigel, Helmut Sigel, Roland K.O. Sigel


Selenium is an essential micronutrient in mammals, but is also recognized as toxic in excess. It is a non-metal with properties that are intermediate between the chalcogen elements sulfur and tellurium. Selenium exerts its biological functions through selenoproteins. Selenoproteins contain selenium in the form of the 21st amino acid, selenocysteine (Sec), which is an analog of cysteine with the sulfur-containing side chain replaced by a Se-containing side chain. Sec is encoded by the codon UGA, which is one of three termination codons for mRNA translation in non-selenoprotein genes. Recognition of the UGA codon as a Sec insertion site instead of stop requires a Sec insertion sequence (SECIS) element in selenoprotein mRNAs and a unique selenocysteyl-tRNA, both of which are recognized by specialized protein factors. Unlike the 20 standard amino acids, Sec is biosynthesized from serine on its tRNA. Twenty-five selenoproteins are encoded in the human genome. Most of the selenoprotein genes were discovered by bioinformatics approaches, searching for SECIS elements downstream of in-frame UGA codons. Sec has been described as having stronger nucleophilic and electrophilic properties than cysteine, and Sec is present in the catalytic site of all selenoenzymes. Most selenoproteins, whose functions are known, are involved in redox systems and signaling pathways. However, several selenoproteins are not well characterized in terms of their function. The selenium field has grown dramatically in the last few decades, and research on selenium biology is providing extensive new information regarding its importance for human health.

Mendeley readers

The data shown below were compiled from readership statistics for 67 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 67 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 12 18%
Student > Ph. D. Student 10 15%
Student > Bachelor 9 13%
Researcher 9 13%
Student > Doctoral Student 5 7%
Other 4 6%
Unknown 18 27%
Readers by discipline Count As %
Agricultural and Biological Sciences 8 12%
Medicine and Dentistry 8 12%
Pharmacology, Toxicology and Pharmaceutical Science 8 12%
Biochemistry, Genetics and Molecular Biology 8 12%
Nursing and Health Professions 5 7%
Other 8 12%
Unknown 22 33%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 July 2014.
All research outputs
of 17,361,274 outputs
Outputs from Metal ions in life sciences
of 118 outputs
Outputs of similar age
of 340,753 outputs
Outputs of similar age from Metal ions in life sciences
of 2 outputs
Altmetric has tracked 17,361,274 research outputs across all sources so far. This one is in the 47th percentile – i.e., 47% of other outputs scored the same or lower than it.
So far Altmetric has tracked 118 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.5. This one is in the 6th percentile – i.e., 6% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 340,753 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 61% of its contemporaries.
We're also able to compare this research output to 2 others from the same source and published within six weeks on either side of this one.