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Interrelations between Essential Metal Ions and Human Diseases

Overview of attention for book
Attention for Chapter 8: Iron: Effect of Overload and Deficiency
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  • Among the highest-scoring outputs from this source (#47 of 135)
  • Average Attention Score compared to outputs of the same age

Mentioned by

24 Wikipedia pages


198 Dimensions

Readers on

74 Mendeley
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Chapter title
Iron: Effect of Overload and Deficiency
Chapter number 8
Book title
Interrelations between Essential Metal Ions and Human Diseases
Published in
Metal ions in life sciences, November 2013
DOI 10.1007/978-94-007-7500-8_8
Pubmed ID
Book ISBNs
978-9-40-077499-5, 978-9-40-077500-8

Robert C. Hider, Xiaole Kong, Hider, Robert C., Kong, Xiaole


Astrid Sigel, Helmut Sigel, Roland K.O. Sigel


Iron is a redox active metal which is abundant in the Earth's crust. It has played a key role in the evolution of living systems and as such is an essential element in a wide range of biological phenomena, being critical for the function of an enormous array of enzymes, energy transduction mechanisms, and oxygen carriers. The redox nature of iron renders the metal toxic in excess and consequently all biological organisms carefully control iron levels. In this overview the mechanisms adopted by man to control body iron levels are described.Low body iron levels are related to anemia which can be treated by various forms of iron fortification and supplementation. Elevated iron levels can occur systemically or locally, each giving rise to specific symptoms. Systemic iron overload results from either the hyperabsorption of iron or regular blood transfusion and can be treated by the use of a selection of iron chelating molecules. The symptoms of many forms of neurodegeneration are associated with elevated levels of iron in certain regions of the brain and iron chelation therapy is beginning to find an application in the treatment of such diseases. Iron chelators have also been widely investigated for the treatment of cancer, tuberculosis, and malaria. In these latter studies, selective removal of iron from key enzymes or iron binding proteins is sought. Sufficient selectivity between the invading organism and the host has yet to be established for such chelators to find application in the clinic.Iron chelation for systemic iron overload and iron supplementation therapy for the treatment of various forms of anemia are now established procedures in clinical medicine. Chelation therapy may find an important role in the treatment of various neurodegenerative diseases in the near future.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 74 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 74 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 14 19%
Student > Ph. D. Student 12 16%
Student > Master 6 8%
Researcher 5 7%
Student > Postgraduate 3 4%
Other 7 9%
Unknown 27 36%
Readers by discipline Count As %
Medicine and Dentistry 15 20%
Chemistry 7 9%
Biochemistry, Genetics and Molecular Biology 6 8%
Nursing and Health Professions 3 4%
Agricultural and Biological Sciences 3 4%
Other 13 18%
Unknown 27 36%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 January 2023.
All research outputs
of 23,505,010 outputs
Outputs from Metal ions in life sciences
of 135 outputs
Outputs of similar age
of 306,005 outputs
Outputs of similar age from Metal ions in life sciences
of 19 outputs
Altmetric has tracked 23,505,010 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 135 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.1. This one is in the 5th percentile – i.e., 5% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 306,005 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 48th percentile – i.e., 48% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 19 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.