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Interrelations between Essential Metal Ions and Human Diseases

Overview of attention for book
Attention for Chapter 8: Iron: Effect of Overload and Deficiency
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About this Attention Score

  • Among the highest-scoring outputs from this source (#47 of 133)
  • Above-average Attention Score compared to outputs of the same age (55th percentile)

Mentioned by

23 Wikipedia pages


142 Dimensions

Readers on

63 Mendeley
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Chapter title
Iron: Effect of Overload and Deficiency
Chapter number 8
Book title
Interrelations between Essential Metal Ions and Human Diseases
Published in
Metal ions in life sciences, November 2013
DOI 10.1007/978-94-007-7500-8_8
Pubmed ID
Book ISBNs
978-9-40-077499-5, 978-9-40-077500-8

Robert C. Hider, Xiaole Kong, Hider, Robert C., Kong, Xiaole


Astrid Sigel, Helmut Sigel, Roland K.O. Sigel


Iron is a redox active metal which is abundant in the Earth's crust. It has played a key role in the evolution of living systems and as such is an essential element in a wide range of biological phenomena, being critical for the function of an enormous array of enzymes, energy transduction mechanisms, and oxygen carriers. The redox nature of iron renders the metal toxic in excess and consequently all biological organisms carefully control iron levels. In this overview the mechanisms adopted by man to control body iron levels are described.Low body iron levels are related to anemia which can be treated by various forms of iron fortification and supplementation. Elevated iron levels can occur systemically or locally, each giving rise to specific symptoms. Systemic iron overload results from either the hyperabsorption of iron or regular blood transfusion and can be treated by the use of a selection of iron chelating molecules. The symptoms of many forms of neurodegeneration are associated with elevated levels of iron in certain regions of the brain and iron chelation therapy is beginning to find an application in the treatment of such diseases. Iron chelators have also been widely investigated for the treatment of cancer, tuberculosis, and malaria. In these latter studies, selective removal of iron from key enzymes or iron binding proteins is sought. Sufficient selectivity between the invading organism and the host has yet to be established for such chelators to find application in the clinic.Iron chelation for systemic iron overload and iron supplementation therapy for the treatment of various forms of anemia are now established procedures in clinical medicine. Chelation therapy may find an important role in the treatment of various neurodegenerative diseases in the near future.

Mendeley readers

The data shown below were compiled from readership statistics for 63 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 63 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 14 22%
Student > Ph. D. Student 10 16%
Student > Master 5 8%
Researcher 5 8%
Student > Doctoral Student 3 5%
Other 8 13%
Unknown 18 29%
Readers by discipline Count As %
Medicine and Dentistry 15 24%
Biochemistry, Genetics and Molecular Biology 6 10%
Chemistry 6 10%
Agricultural and Biological Sciences 3 5%
Nursing and Health Professions 2 3%
Other 13 21%
Unknown 18 29%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 January 2022.
All research outputs
of 21,681,896 outputs
Outputs from Metal ions in life sciences
of 133 outputs
Outputs of similar age
of 323,904 outputs
Outputs of similar age from Metal ions in life sciences
of 2 outputs
Altmetric has tracked 21,681,896 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 133 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.0. This one is in the 6th percentile – i.e., 6% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 323,904 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 55% of its contemporaries.
We're also able to compare this research output to 2 others from the same source and published within six weeks on either side of this one.