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Interrelations between Essential Metal Ions and Human Diseases

Overview of attention for book
Attention for Chapter 4: Calcium in Health and Disease
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About this Attention Score

  • Among the highest-scoring outputs from this source (#47 of 133)
  • Average Attention Score compared to outputs of the same age

Mentioned by

15 Wikipedia pages


142 Dimensions

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98 Mendeley
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Chapter title
Calcium in Health and Disease
Chapter number 4
Book title
Interrelations between Essential Metal Ions and Human Diseases
Published in
Metal ions in life sciences, November 2013
DOI 10.1007/978-94-007-7500-8_4
Pubmed ID
Book ISBNs
978-9-40-077499-5, 978-9-40-077500-8

Marisa Brini, Denis Ottolini, Tito Calì, Ernesto Carafoli, Brini, Marisa, Ottolini, Denis, Calì, Tito, Carafoli, Ernesto


Astrid Sigel, Helmut Sigel, Roland K.O. Sigel


Evolution has exploited the chemical properties of Ca(2+), which facilitate its reversible binding to the sites of irregular geometry offered by biological macromolecules, to select it as a carrier of cellular signals. A number of proteins bind Ca(2+) to specific sites: those intrinsic to membranes play the most important role in the spatial and temporal regulation of the concentration and movements of Ca(2+) inside cells. Those which are soluble, or organized in non-membranous structures, also decode the Ca(2+) message to be then transmitted to the targets of its regulation. Since Ca(2+) controls the most important processes in the life of cells, it must be very carefully controlled within the cytoplasm, where most of the targets of its signaling function reside. Membrane channels (in the plasma membrane and in the organelles) mediate the entrance of Ca(2+) into the cytoplasm, ATPases, exchangers, and the mitochondrial Ca(2+) uptake system remove Ca(2+) from it. The concentration of Ca(2+) in the external spaces, which is controlled essentially by its dynamic exchanges in the bone system, is much higher than inside cells, and can, under conditions of pathology, generate a situation of dangerous internal Ca(2+) overload. When massive and persistent, the Ca(2+) overload culminates in the death of the cell. Subtle conditions of cellular Ca(2+) dyshomeostasis that affect individual systems that control Ca(2+), generate cell disease phenotypes that are particularly severe in tissues in which the signaling function of Ca(2+) has special importance, e.g., the nervous system.

Mendeley readers

The data shown below were compiled from readership statistics for 98 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 1%
India 1 1%
Unknown 96 98%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 19 19%
Researcher 14 14%
Student > Ph. D. Student 13 13%
Student > Master 12 12%
Professor > Associate Professor 4 4%
Other 14 14%
Unknown 22 22%
Readers by discipline Count As %
Agricultural and Biological Sciences 16 16%
Medicine and Dentistry 14 14%
Biochemistry, Genetics and Molecular Biology 13 13%
Chemistry 6 6%
Neuroscience 3 3%
Other 18 18%
Unknown 28 29%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 November 2022.
All research outputs
of 22,432,156 outputs
Outputs from Metal ions in life sciences
of 133 outputs
Outputs of similar age
of 309,016 outputs
Outputs of similar age from Metal ions in life sciences
of 3 outputs
Altmetric has tracked 22,432,156 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 133 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.1. This one is in the 5th percentile – i.e., 5% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 309,016 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 50% of its contemporaries.
We're also able to compare this research output to 3 others from the same source and published within six weeks on either side of this one.