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Interrelations between Essential Metal Ions and Human Diseases

Overview of attention for book
Attention for Chapter 13: Molybdenum in Human Health and Disease
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  • Among the highest-scoring outputs from this source (#47 of 135)
  • Average Attention Score compared to outputs of the same age

Mentioned by

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7 Wikipedia pages

Citations

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190 Dimensions

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64 Mendeley
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Chapter title
Molybdenum in Human Health and Disease
Chapter number 13
Book title
Interrelations between Essential Metal Ions and Human Diseases
Published in
Metal ions in life sciences, November 2013
DOI 10.1007/978-94-007-7500-8_13
Pubmed ID
Book ISBNs
978-9-40-077499-5, 978-9-40-077500-8
Authors

Guenter Schwarz, Abdel A. Belaidi

Editors

Astrid Sigel, Helmut Sigel, Roland K.O. Sigel

Abstract

Molybdenum is an essential trace element and crucial for the survival of animals. Four mammalian Mo-dependent enzymes are known, all of them harboring a pterin-based molybdenum cofactor (Moco) in their active site. In these enzymes, molybdenum catalyzes oxygen transfer reactions from or to substrates using water as oxygen donor or acceptor. Molybdenum shuttles between two oxidation states, Mo(IV) and Mo(VI). Following substrate reduction or oxidation, electrons are subsequently shuttled by either inter- or intra-molecular electron transfer chains involving prosthetic groups such as heme or iron-sulfur clusters. In all organisms studied so far, Moco is synthesized by a highly conserved multi-step biosynthetic pathway. A deficiency in the biosynthesis of Moco results in a pleitropic loss of all four human Mo-enzyme activities and in most cases in early childhood death. In this review we first introduce general aspects of molybdenum biochemistry before we focus on the functions and deficiencies of two Mo-enzymes, xanthine dehydrogenase and sulfite oxidase, caused either by deficiency of the apo-protein or a pleiotropic loss of Moco due to a genetic defect in its biosynthesis. The underlying molecular basis of Moco deficiency, possible treatment options and links to other diseases, such as neuropsychiatric disorders, will be discussed.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 64 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 2%
Unknown 63 98%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 15 23%
Student > Ph. D. Student 9 14%
Researcher 7 11%
Student > Doctoral Student 4 6%
Student > Master 4 6%
Other 8 13%
Unknown 17 27%
Readers by discipline Count As %
Agricultural and Biological Sciences 8 13%
Biochemistry, Genetics and Molecular Biology 5 8%
Nursing and Health Professions 5 8%
Chemistry 5 8%
Medicine and Dentistry 5 8%
Other 17 27%
Unknown 19 30%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 March 2023.
All research outputs
#7,744,540
of 23,549,388 outputs
Outputs from Metal ions in life sciences
#47
of 135 outputs
Outputs of similar age
#92,521
of 306,195 outputs
Outputs of similar age from Metal ions in life sciences
#11
of 19 outputs
Altmetric has tracked 23,549,388 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 135 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.3. This one is in the 5th percentile – i.e., 5% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 306,195 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 48th percentile – i.e., 48% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 19 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.