| Chapter title |
Human Telomeric G-Quadruplex Structures and G-Quadruplex-Interactive Compounds
|
|---|---|
| Chapter number | 17 |
| Book title |
Telomeres and Telomerase
|
| Published in |
Methods in molecular biology, March 2017
|
| DOI | 10.1007/978-1-4939-6892-3_17 |
| Pubmed ID | |
| Book ISBNs |
978-1-4939-6891-6, 978-1-4939-6892-3
|
| Authors |
Clement Lin, Danzhou Yang |
| Editors |
Zhou Songyang |
| Abstract |
G-quadruplexes are noncanonical secondary structures formed in DNA sequences containing consecutive runs of guanines. It has been shown that the 3' G-rich single-stranded overhangs of human telomeres can form G-quadruplex structures, and the human telomeric DNA G-quadruplexes are considered attractive targets for anticancer drugs. G-quadruplex-interactive compounds have been shown to inhibit telomerase access as well as telomere capping. Nuclear magnetic resonance (NMR) spectroscopy is a powerful method in determining the G-quadruplex structures under physiologically relevant conditions. We present the NMR and biophysical methodology used in our research group for the study of G-quadruplex structures in physiologically relevant solution and their interactions with small-molecule compounds. |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 78 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 15 | 19% |
| Student > Bachelor | 13 | 17% |
| Student > Master | 10 | 13% |
| Researcher | 4 | 5% |
| Student > Doctoral Student | 3 | 4% |
| Other | 7 | 9% |
| Unknown | 26 | 33% |
| Readers by discipline | Count | As % |
|---|---|---|
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| Agricultural and Biological Sciences | 5 | 6% |
| Medicine and Dentistry | 3 | 4% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 3% |
| Other | 6 | 8% |
| Unknown | 28 | 36% |