Telomeres and Telomerase
Springer New York
Chapter title |
Cytogenetic Analysis of Telomere Dysfunction
|
---|---|
Chapter number | 12 |
Book title |
Telomeres and Telomerase
|
Published in |
Methods in molecular biology, March 2017
|
DOI | 10.1007/978-1-4939-6892-3_12 |
Pubmed ID | |
Book ISBNs |
978-1-4939-6891-6, 978-1-4939-6892-3
|
Authors |
Rekha Rai, Asha S. Multani, Sandy Chang |
Editors |
Zhou Songyang |
Abstract |
Dysfunctional telomeres arising either through natural attrition due to telomerase deficiency or by the removal of telomere-binding proteins are recognized as double-stranded breaks (DSBs). Repair of DSBs is crucial for the maintenance of genome stability. In mammals, DSBs are repaired by either error-prone nonhomologous end joining (NHEJ) or error-free homologous recombination (HR) and can be visualized as chromosomal fusions. |
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Unknown | 7 | 100% |
Readers by professional status | Count | As % |
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Student > Doctoral Student | 1 | 14% |
Student > Ph. D. Student | 1 | 14% |
Student > Master | 1 | 14% |
Researcher | 1 | 14% |
Professor > Associate Professor | 1 | 14% |
Other | 0 | 0% |
Unknown | 2 | 29% |
Readers by discipline | Count | As % |
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Engineering | 1 | 14% |
Unknown | 2 | 29% |