Telomeres and Telomerase
Springer New York
Chapter title |
Telomere Length Analysis by Quantitative Fluorescent in Situ Hybridization (Q-FISH)
|
---|---|
Chapter number | 3 |
Book title |
Telomeres and Telomerase
|
Published in |
Methods in molecular biology, March 2017
|
DOI | 10.1007/978-1-4939-6892-3_3 |
Pubmed ID | |
Book ISBNs |
978-1-4939-6891-6, 978-1-4939-6892-3
|
Authors |
Isabelle Ourliac-Garnier, Arturo Londoño-Vallejo |
Editors |
Zhou Songyang |
Abstract |
Length is a functional parameter of telomeres, the nucleoprotein structures that protect chromosome ends. The availability of highly specific, high affinity probes for telomeric repeat sequences allowed the development of quantitative approaches aimed at measuring telomere length directly on chromosomes or in interphase nuclei. Here, we describe a general method for telomere quantitative FISH on metaphase chromosomes and discuss its most common applications in research. |
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