| Chapter title |
A Modified Aortic Ring Assay to Assess Angiogenic Potential In Vitro
|
|---|---|
| Chapter number | 14 |
| Book title |
Angiogenesis Protocols
|
| Published in |
Methods in molecular biology, January 2016
|
| DOI | 10.1007/978-1-4939-3628-1_14 |
| Pubmed ID | |
| Book ISBNs |
978-1-4939-3626-7, 978-1-4939-3628-1
|
| Authors |
Nina Zippel, Yindi Ding, Ingrid Fleming |
| Abstract |
Angiogenesis, an integral part of many physiological and pathological processes, is a tightly regulated multistep process. Angiogenesis assays are used to clarify the molecular mechanisms and screen for pharmacological inhibitors. However, most in vitro angiogenesis models measure only one aspect of this process, whereas in vivo assays are complex and difficult to interpret. The ex vivo aortic ring model allows the study of many key features of angiogenesis, such as endothelial activation, branching, and remodeling as well as later steps such as pericyte acquisition. This model can be modified to include genetic manipulation and can be used to assess the pro- or anti-angiogenic effects of compounds in a relatively controlled system. |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 15 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 3 | 20% |
| Student > Master | 3 | 20% |
| Other | 2 | 13% |
| Student > Bachelor | 2 | 13% |
| Professor | 1 | 7% |
| Other | 2 | 13% |
| Unknown | 2 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 5 | 33% |
| Medicine and Dentistry | 3 | 20% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 13% |
| Agricultural and Biological Sciences | 1 | 7% |
| Chemistry | 1 | 7% |
| Other | 1 | 7% |
| Unknown | 2 | 13% |