Chapter title |
Antiviral Strategies Against Chikungunya Virus
|
---|---|
Chapter number | 22 |
Book title |
Chikungunya Virus
|
Published in |
Methods in molecular biology, May 2016
|
DOI | 10.1007/978-1-4939-3618-2_22 |
Pubmed ID | |
Book ISBNs |
978-1-4939-3616-8, 978-1-4939-3618-2
|
Authors |
Rana Abdelnabi, Johan Neyts, Leen Delang |
Editors |
Justin Jang Hann Chu, Swee Kim Ang |
Abstract |
In the last few decades the Chikungunya virus (CHIKV) has evolved from a geographically isolated pathogen to a virus that is widespread in many parts of Africa, Asia and recently also in Central- and South-America. Although CHIKV infections are rarely fatal, the disease can evolve into a chronic stage, which is characterized by persisting polyarthralgia and joint stiffness. This chronic CHIKV infection can severely incapacitate patients for weeks up to several years after the initial infection. Despite the burden of CHIKV infections, no vaccine or antivirals are available yet. The current therapy is therefore only symptomatic and consists of the administration of analgesics, antipyretics, and anti-inflammatory agents. Recently several molecules with various viral or host targets have been identified as CHIKV inhibitors. In this chapter, we summarize the current status of the development of antiviral strategies against CHIKV infections. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 1 | 2% |
Unknown | 63 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 13 | 20% |
Student > Master | 8 | 13% |
Student > Doctoral Student | 8 | 13% |
Student > Ph. D. Student | 5 | 8% |
Student > Bachelor | 4 | 6% |
Other | 11 | 17% |
Unknown | 15 | 23% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 14 | 22% |
Medicine and Dentistry | 6 | 9% |
Agricultural and Biological Sciences | 6 | 9% |
Immunology and Microbiology | 5 | 8% |
Pharmacology, Toxicology and Pharmaceutical Science | 4 | 6% |
Other | 10 | 16% |
Unknown | 19 | 30% |