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Drug Target miRNA

Overview of attention for book
Cover of 'Drug Target miRNA'

Table of Contents

  1. Altmetric Badge
    Book Overview
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    Chapter 1 miRNA Targeting Drugs: The Next Blockbusters?
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    Chapter 2 Functional Analysis of miRNAs Using the DIANA Tools Online Suite.
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    Chapter 3 Non-nucleotide Modification of Anti-miRNA Oligonucleotides.
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    Chapter 4 Quantification of Oligonucleotide Association with miRNA-Argonaute Complexes In Vitro.
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    Chapter 5 Determination of Anti-miR Association with miRNA/Argonaute Complexes In Vivo.
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    Chapter 6 Competitive Argonaute-Based RNA Immunoprecipitation for Investigation of Transcriptomic Response to Anti-miR.
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    Chapter 7 Assessing Anti-miR Pharmacology with miRNA Polysome Shift Assay.
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    Chapter 8 Evaluating Synergistic Effects of miR-34a Mimics in Combination with Other Therapeutic Agents in Cultured Non-Small Cell Lung Cancer Cells.
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    Chapter 9 Assessing the Off-Target Effects of miRNA Inhibitors on Innate Immune Toll-Like Receptors.
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    Chapter 10 Design of Multimodal Small Molecules Targeting miRNAs Biogenesis: Synthesis and In Vitro Evaluation.
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    Chapter 11 Machine Learning Approaches Toward Building Predictive Models for Small Molecule Modulators of miRNA and Its Utility in Virtual Screening of Molecular Databases.
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    Chapter 12 Identification of Small Molecule Modulators of MicroRNA by Library Screening.
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    Chapter 13 Rapid Generation of miRNA Inhibitor Leads by Bioinformatics and Efficient High-Throughput Screening Methods.
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    Chapter 14 Drug Target miRNA
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    Chapter 15 Small Molecules Targeting the miRNA-Binding Domain of Argonaute 2: From Computer-Aided Molecular Design to RNA Immunoprecipitation.
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    Chapter 16 Surface Plasmon Resonance: A Useful Strategy for the Identification of Small Molecule Argonaute 2 Protein Binders.
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    Chapter 17 Antagonists of the miRNA-Argonaute 2 Protein Complex: Anti-miR-AGOs.
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    Chapter 18 Elucidating Mechanisms of Molecular Recognition Between Human Argonaute and miRNA Using Computational Approaches.
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    Chapter 19 Kinetic Analysis of Target RNA Binding and Slicing by Human Argonaute 2 Protein.
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    Chapter 20 Site-Specific Fluorescent Labeling of Argonaute for FRET-Based Bio-Assays.
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    Chapter 21 Single-Molecule Fluorescence Energy Transfer Assays for the Characterization of Reaction Pathways of miRNA-Argonaute Complex.
Attention for Chapter 7: Assessing Anti-miR Pharmacology with miRNA Polysome Shift Assay.
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (77th percentile)
  • High Attention Score compared to outputs of the same age and source (84th percentile)

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1 news outlet

Citations

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5 Dimensions

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4 Mendeley
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Chapter title
Assessing Anti-miR Pharmacology with miRNA Polysome Shift Assay.
Chapter number 7
Book title
Drug Target miRNA
Published in
Methods in molecular biology, January 2017
DOI 10.1007/978-1-4939-6563-2_7
Pubmed ID
27924477
Book ISBNs
978-1-4939-6561-8, 978-1-4939-6563-2
Authors

John R. Androsavich, Androsavich, John R.

Editors

Marco F. Schmidt

Abstract

Target engagement measurements are critical for evaluating developmental drug candidates and their pharmacological activity. microRNA (miRNA) Polysome Shift Assay enables measurement of anti-miR drug target engagement (i.e. extent of miRNA inhibition) without the need to pre-identify or pre-validate downstream miRNA-regulated genes. This makes it useful for assessing anti-miR activity in target tissues or cells where biology of the inhibited miRNAs may not be well understood. In addition, miRNA Polysome Shift Assay can be multiplexed to assess inhibition of multiple miRNAs by a single anti-miR, thus guiding drug optimization for enhancing or avoiding these activities as desired. This chapter outlines the miRNA Polysome Shift Assay technique, describes sample preparation and quality control, and how to calculate and interpret results.

View on publisher site
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 4 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 4 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 2 50%
Student > Ph. D. Student 1 25%
Student > Master 1 25%
Readers by discipline Count As %
Agricultural and Biological Sciences 2 50%
Medicine and Dentistry 2 50%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 May 2024.
All research outputs
#4,969,756
of 25,893,933 outputs
Outputs from Methods in molecular biology
#1,331
of 14,400 outputs
Outputs of similar age
#88,616
of 424,899 outputs
Outputs of similar age from Methods in molecular biology
#137
of 1,089 outputs
Altmetric has tracked 25,893,933 research outputs across all sources so far. Compared to these this one has done well and is in the 79th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 14,400 research outputs from this source. They receive a mean Attention Score of 3.5. This one has done well, scoring higher than 89% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 424,899 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 77% of its contemporaries.
We're also able to compare this research output to 1,089 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 84% of its contemporaries.

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