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Mendeley readers
Chapter title |
Design of Multimodal Small Molecules Targeting miRNAs Biogenesis: Synthesis and In Vitro Evaluation.
|
---|---|
Chapter number | 10 |
Book title |
Drug Target miRNA
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Published in |
Methods in molecular biology, January 2017
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DOI | 10.1007/978-1-4939-6563-2_10 |
Pubmed ID | |
Book ISBNs |
978-1-4939-6561-8, 978-1-4939-6563-2
|
Authors |
Duc D. Vo, Maria Duca |
Editors |
Marco F. Schmidt |
Abstract |
microRNAs (miRNAs) are emerging as novel biological targets for medicinal chemists to develop chemical tools for intracellular regulation. In this context, the discovery of small-molecule drugs targeting specific miRNAs and modulating their production or function represents a very promising approach that could be further developed for targeted therapy in miRNA-related pathologies. Here, we describe the design of multimodal small molecules as RNA ligands targeting DICER-mediated miRNA maturation. The synthesis and the biochemical evaluation as ligands of stem-loop-structured precursor microRNAs (pre-miRNAs) are reported. |
Mendeley readers
The data shown below were compiled from readership statistics for 7 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 7 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 3 | 43% |
Student > Master | 1 | 14% |
Unknown | 3 | 43% |
Readers by discipline | Count | As % |
---|---|---|
Chemistry | 4 | 57% |
Unknown | 3 | 43% |