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Mendeley readers
Chapter title |
Identification of Small Molecule Modulators of MicroRNA by Library Screening.
|
---|---|
Chapter number | 12 |
Book title |
Drug Target miRNA
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Published in |
Methods in molecular biology, January 2017
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DOI | 10.1007/978-1-4939-6563-2_12 |
Pubmed ID | |
Book ISBNs |
978-1-4939-6561-8, 978-1-4939-6563-2
|
Authors |
Zhangang Xiao, Yangchao Chen Ph.D., Yangchao Chen |
Editors |
Marco F. Schmidt |
Abstract |
MicroRNAs (miRNAs) function as oncogenes or tumor suppressors and are dysregulated in cancer. miRNAs therefore represent promising therapeutic targets for cancer. Small molecules that could modulate the expression of miRNAs would thus have potential as anticancer agents. Library screening of small molecules targeting miRNAs is a useful technology platform for anticancer drug development. Here, we describe a hepatocellular carcinoma (HCC) cell-based luciferase reporter system which could be used to screen for small molecule modulators of tumor suppressor microRNA-34a. |
Mendeley readers
The data shown below were compiled from readership statistics for 5 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 5 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Lecturer > Senior Lecturer | 1 | 20% |
Librarian | 1 | 20% |
Student > Bachelor | 1 | 20% |
Student > Master | 1 | 20% |
Researcher | 1 | 20% |
Other | 0 | 0% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 3 | 60% |
Arts and Humanities | 1 | 20% |
Medicine and Dentistry | 1 | 20% |