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Mendeley readers
Chapter title |
Assessing the Off-Target Effects of miRNA Inhibitors on Innate Immune Toll-Like Receptors.
|
---|---|
Chapter number | 9 |
Book title |
Drug Target miRNA
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Published in |
Methods in molecular biology, January 2017
|
DOI | 10.1007/978-1-4939-6563-2_9 |
Pubmed ID | |
Book ISBNs |
978-1-4939-6561-8, 978-1-4939-6563-2
|
Authors |
Geneviève Pépin, Jonathan Ferrand, Michael P. Gantier |
Editors |
Marco F. Schmidt |
Abstract |
MicroRNAs (miRNAs) are involved in most cellular processes and are deregulated in several diseases. Antisense miRNA oligonucleotides (AMOs) therefore present novel therapeutic opportunities. Currently, in vivo delivery of AMOs often relies on high doses of nucleic acids, with nonspecific uptake by most tissues. Critically, AMOs accumulate in phagocytic cells where they can interfere with immune functions, such as the activation of Toll-Like Receptors (TLRs). In this chapter, we describe a method to assess the possible off-target effects of AMOs on TLR7, 8, and 9 sensing. |
Mendeley readers
The data shown below were compiled from readership statistics for 7 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 7 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 2 | 29% |
Student > Ph. D. Student | 1 | 14% |
Student > Bachelor | 1 | 14% |
Student > Doctoral Student | 1 | 14% |
Unknown | 2 | 29% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 2 | 29% |
Biochemistry, Genetics and Molecular Biology | 1 | 14% |
Immunology and Microbiology | 1 | 14% |
Medicine and Dentistry | 1 | 14% |
Unknown | 2 | 29% |