↓ Skip to main content

RNA Vaccines

Overview of attention for book
Cover of 'RNA Vaccines'

Table of Contents

  1. Altmetric Badge
    Book Overview
  2. Altmetric Badge
    Chapter 1 Introduction to RNA Vaccines.
  3. Altmetric Badge
    Chapter 2 Self-Replicating RNA.
  4. Altmetric Badge
    Chapter 3 Self-Replicating RNA Vaccine Delivery to Dendritic Cells.
  5. Altmetric Badge
    Chapter 4 Plant Expression of Trans-Encapsidated Viral Nanoparticle Vaccines with Animal RNA Replicons.
  6. Altmetric Badge
    Chapter 5 RNActive® Technology: Generation and Testing of Stable and Immunogenic mRNA Vaccines.
  7. Altmetric Badge
    Chapter 6 Nucleoside Modified mRNA Vaccines for Infectious Diseases.
  8. Altmetric Badge
    Chapter 7 Generation and Evaluation of Prophylactic mRNA Vaccines Against Allergy.
  9. Altmetric Badge
    Chapter 8 Measuring the Adjuvant Activity of RNA Vaccines.
  10. Altmetric Badge
    Chapter 9 Generation of Immunostimulating 130 nm Protamine-RNA nanoparticles.
  11. Altmetric Badge
    Chapter 10 Electroporation of mRNA as Universal Technology Platform to Transfect a Variety of Primary Cells with Antigens and Functional Proteins.
  12. Altmetric Badge
    Chapter 11 Adjuvant-Enhanced mRNA Vaccines.
  13. Altmetric Badge
    Chapter 12 Enhanced Delivery of DNA or RNA Vaccines by Electroporation.
  14. Altmetric Badge
    Chapter 13 The European Regulatory Environment of RNA-Based Vaccines.
  15. Altmetric Badge
    Chapter 14 Discovery and Subtyping of Neo-Epitope Specific T-Cell Responses for Cancer Immunotherapy: Addressing the Mutanome.
  16. Altmetric Badge
    Chapter 15 Considerations for Producing mRNA Vaccines for Clinical Trials.
  17. Altmetric Badge
    Chapter 16 Nonclinical Safety Testing of RNA Vaccines.
  18. Altmetric Badge
    Chapter 17 Immunotherapy of Uveal Melanoma: Vaccination Against Cancer.
Attention for Chapter 17: Immunotherapy of Uveal Melanoma: Vaccination Against Cancer.
Altmetric Badge

Citations

dimensions_citation
10 Dimensions

Readers on

mendeley
10 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Chapter title
Immunotherapy of Uveal Melanoma: Vaccination Against Cancer.
Chapter number 17
Book title
RNA Vaccines
Published in
Methods in molecular biology, January 2017
DOI 10.1007/978-1-4939-6481-9_17
Pubmed ID
Book ISBNs
978-1-4939-6479-6, 978-1-4939-6481-9
Authors

Mirko Kummer, Beatrice Schuler-Thurner

Editors

Thomas Kramps, Knut Elbers

Abstract

Uveal melanoma is the most frequently occurring primary intraocular tumor in adults, with an incidence of about 5 out of 100,000 per year, the incidence rising with increasing age (Lipski, Klin Monbl Augenheilkd 230:1005-1019, 2013; Metz et al., Klin Monbl Augenheilkd 230:686-691, 2013; Singh and Topham, Ophthalmology 110:956-961, 2003). Often diagnosed late due to a lack of early symptoms, this kind of melanoma is associated with a poor prognosis. Approximately 50 % of the patients develop distant metastases (Lipski, Klin Monbl Augenheilkd 230:1005-1019, 2013; Metz et al., Klin Monbl Augenheilkd 230:686-691, 2013; Singh and Topham, Ophthalmology 110:956-961, 2003). In sharp contrast to cutaneous melanoma, uveal melanoma shows a strong liver tropism and spreads exclusively via the hematogenous route (except for tumors with extraocular expansion) (Heindl et al., Arch Ophthalmol 128:1001-1008, 2010). The most likely reason for this observation is the lack of lymphatic vessels in the choroid and alymphatic barrier of the sclera (Schlereth et al., Exp Eye Res 125:203-209, 2014; Schroedl et al., Invest Ophthalmol Vis Sci 49:5222-5229, 2008). Due to its location in the immune-privileged eye, the uveal melanoma is widely protected from the immune system. Therefore, the goal of the approach presented here, of a "personalized vaccination therapy" is to help the immune system recognize and fight the tumor.

Mendeley readers

The data shown below were compiled from readership statistics for 10 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 10 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 4 40%
Student > Master 2 20%
Student > Doctoral Student 1 10%
Student > Ph. D. Student 1 10%
Professor > Associate Professor 1 10%
Other 1 10%
Readers by discipline Count As %
Medicine and Dentistry 5 50%
Pharmacology, Toxicology and Pharmaceutical Science 1 10%
Materials Science 1 10%
Biochemistry, Genetics and Molecular Biology 1 10%
Unknown 2 20%