Chapter title |
Immunotherapy of Uveal Melanoma: Vaccination Against Cancer.
|
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Chapter number | 17 |
Book title |
RNA Vaccines
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Published in |
Methods in molecular biology, January 2017
|
DOI | 10.1007/978-1-4939-6481-9_17 |
Pubmed ID | |
Book ISBNs |
978-1-4939-6479-6, 978-1-4939-6481-9
|
Authors |
Mirko Kummer, Beatrice Schuler-Thurner |
Editors |
Thomas Kramps, Knut Elbers |
Abstract |
Uveal melanoma is the most frequently occurring primary intraocular tumor in adults, with an incidence of about 5 out of 100,000 per year, the incidence rising with increasing age (Lipski, Klin Monbl Augenheilkd 230:1005-1019, 2013; Metz et al., Klin Monbl Augenheilkd 230:686-691, 2013; Singh and Topham, Ophthalmology 110:956-961, 2003). Often diagnosed late due to a lack of early symptoms, this kind of melanoma is associated with a poor prognosis. Approximately 50 % of the patients develop distant metastases (Lipski, Klin Monbl Augenheilkd 230:1005-1019, 2013; Metz et al., Klin Monbl Augenheilkd 230:686-691, 2013; Singh and Topham, Ophthalmology 110:956-961, 2003). In sharp contrast to cutaneous melanoma, uveal melanoma shows a strong liver tropism and spreads exclusively via the hematogenous route (except for tumors with extraocular expansion) (Heindl et al., Arch Ophthalmol 128:1001-1008, 2010). The most likely reason for this observation is the lack of lymphatic vessels in the choroid and alymphatic barrier of the sclera (Schlereth et al., Exp Eye Res 125:203-209, 2014; Schroedl et al., Invest Ophthalmol Vis Sci 49:5222-5229, 2008). Due to its location in the immune-privileged eye, the uveal melanoma is widely protected from the immune system. Therefore, the goal of the approach presented here, of a "personalized vaccination therapy" is to help the immune system recognize and fight the tumor. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 10 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 4 | 40% |
Student > Master | 2 | 20% |
Student > Doctoral Student | 1 | 10% |
Student > Ph. D. Student | 1 | 10% |
Professor > Associate Professor | 1 | 10% |
Other | 1 | 10% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 5 | 50% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 10% |
Materials Science | 1 | 10% |
Biochemistry, Genetics and Molecular Biology | 1 | 10% |
Unknown | 2 | 20% |