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RNA Vaccines

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Cover of 'RNA Vaccines'

Table of Contents

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    Book Overview
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    Chapter 1 Introduction to RNA Vaccines.
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    Chapter 2 Self-Replicating RNA.
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    Chapter 3 Self-Replicating RNA Vaccine Delivery to Dendritic Cells.
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    Chapter 4 Plant Expression of Trans-Encapsidated Viral Nanoparticle Vaccines with Animal RNA Replicons.
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    Chapter 5 RNActive® Technology: Generation and Testing of Stable and Immunogenic mRNA Vaccines.
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    Chapter 6 Nucleoside Modified mRNA Vaccines for Infectious Diseases.
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    Chapter 7 Generation and Evaluation of Prophylactic mRNA Vaccines Against Allergy.
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    Chapter 8 Measuring the Adjuvant Activity of RNA Vaccines.
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    Chapter 9 Generation of Immunostimulating 130 nm Protamine-RNA nanoparticles.
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    Chapter 10 Electroporation of mRNA as Universal Technology Platform to Transfect a Variety of Primary Cells with Antigens and Functional Proteins.
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    Chapter 11 Adjuvant-Enhanced mRNA Vaccines.
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    Chapter 12 Enhanced Delivery of DNA or RNA Vaccines by Electroporation.
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    Chapter 13 The European Regulatory Environment of RNA-Based Vaccines.
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    Chapter 14 Discovery and Subtyping of Neo-Epitope Specific T-Cell Responses for Cancer Immunotherapy: Addressing the Mutanome.
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    Chapter 15 Considerations for Producing mRNA Vaccines for Clinical Trials.
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    Chapter 16 Nonclinical Safety Testing of RNA Vaccines.
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    Chapter 17 Immunotherapy of Uveal Melanoma: Vaccination Against Cancer.
Attention for Chapter 11: Adjuvant-Enhanced mRNA Vaccines.
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Chapter title
Adjuvant-Enhanced mRNA Vaccines.
Chapter number 11
Book title
RNA Vaccines
Published in
Methods in molecular biology, January 2017
DOI 10.1007/978-1-4939-6481-9_11
Pubmed ID
Book ISBNs
978-1-4939-6479-6, 978-1-4939-6481-9
Authors

Lukasz Bialkowski, Kevin Van der Jeught, Dries Renmans, Alexia van Weijnen, Carlo Heirman, Marleen Keyaerts, Karine Breckpot, Kris Thielemans

Editors

Thomas Kramps, Knut Elbers

Abstract

Recent advances in molecular biology have led to dramatic enhancement of the stability of in vitro transcribed (IVT) messenger RNA (mRNA) and improvement in its translational efficacy. Nowadays, mRNA-based vaccines represent a promising approach in the field of anticancer immunotherapy, gaining attention over the earlier-established bacteria-, virus-, or cell-based vaccination approaches. Here, we present the experimental procedures employed in our laboratory to induce anticancer immune responses in different murine tumor models using IVT mRNA encoding for immune activation signals and antigens of interest.

Mendeley readers

The data shown below were compiled from readership statistics for 26 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 26 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 8 31%
Student > Master 5 19%
Student > Bachelor 3 12%
Researcher 2 8%
Student > Doctoral Student 1 4%
Other 1 4%
Unknown 6 23%
Readers by discipline Count As %
Medicine and Dentistry 5 19%
Immunology and Microbiology 4 15%
Pharmacology, Toxicology and Pharmaceutical Science 3 12%
Biochemistry, Genetics and Molecular Biology 3 12%
Agricultural and Biological Sciences 1 4%
Other 2 8%
Unknown 8 31%