Recommendation Techniques for Drug-Target Interaction Prediction and Drug Repositioning.
Data Mining Techniques for the Life Sciences
Methods in molecular biology, January 2016
Salvatore Alaimo, Rosalba Giugno, Alfredo Pulvirenti
Oliviero Carugo, Frank Eisenhaber
The usage of computational methods in drug discovery is a common practice. More recently, by exploiting the wealth of biological knowledge bases, a novel approach called drug repositioning has raised. Several computational methods are available, and these try to make a high-level integration of all the knowledge in order to discover unknown mechanisms. In this chapter, we review drug-target interaction prediction methods based on a recommendation system. We also give some extensions which go beyond the bipartite network case.
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