Chapter title |
Animal Models Used to Study Superantigen-Mediated Diseases.
|
---|---|
Chapter number | 1 |
Book title |
Superantigens
|
Published in |
Methods in molecular biology, January 2016
|
DOI | 10.1007/978-1-4939-3344-0_1 |
Pubmed ID | |
Book ISBNs |
978-1-4939-3342-6, 978-1-4939-3344-0
|
Authors |
Brosnahan, Amanda J, Amanda J. Brosnahan |
Editors |
Amanda J. Brosnahan |
Abstract |
Superantigens secreted by Staphylococcus aureus and Streptococcus pyogenes interact with the T-cell receptor and major histocompatibility class II molecules on antigen-presenting cells to elicit a massive cytokine release and activation of T cells in higher numbers than that seen with ordinary antigens. Because of this unique ability, superantigens have been implicated as etiological agents for many different types of diseases, including toxic shock syndrome, infective endocarditis, pneumonia, and inflammatory skin diseases. This review covers the main animal models that have been developed in order to identify the roles of superantigens in human disease. |
X Demographics
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
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Korea, Republic of | 1 | 8% |
Unknown | 11 | 92% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 3 | 25% |
Student > Ph. D. Student | 2 | 17% |
Student > Doctoral Student | 1 | 8% |
Student > Master | 1 | 8% |
Other | 1 | 8% |
Other | 0 | 0% |
Unknown | 4 | 33% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 2 | 17% |
Biochemistry, Genetics and Molecular Biology | 1 | 8% |
Veterinary Science and Veterinary Medicine | 1 | 8% |
Computer Science | 1 | 8% |
Agricultural and Biological Sciences | 1 | 8% |
Other | 0 | 0% |
Unknown | 6 | 50% |